Abstract： Objective： To observe the clinical effect of Shenmai injection combined with sacubitril valsartan for chronic heart failure(CHF). Methods：A total of 118 cases of CHF patients were selected and divided into the observation group and the control group according to the random number table method，with 59 cases in each group. The control group was treated with sacubitril valsartan sodium tablets，and the observation group was additionally treated with Shenmai injection based on the treatment of the control group. Before and after treatment， heart function grading， left ventricular ejection fraction (LVEF)，left ventricular end-diastolic diameter(LVDD) and the levels of N-terminal pro-brain natriuretic peptide(NT-proBNP)， soluble CD40 ligand(sCD40L) and pregnancy- associated plasma proteins(PAPP- A) in the two groups were compared. Results： After treatment， the heart function grading in the two groups was decreased when compared with that before treatment(P＜0.05)，and the heart function grading in the observation group was lower than that in the control group(P＜0.05). After treatment，the levels of LVEF in both group were increased when compared with those before treatment(P＜0.05)，the levels of NT-proBNP，sCD40L and PAPP-A were decreased(P＜0.05)，and LVDD were smaller(P＜0.05). The levels of LVEF in the observation group was higher than that in the control group(P＜0.05)，the levels of NT-proBNP，sCD40L and PAPP-A were lower(P＜0.05)， and LVDD was smaller(P＜0.05). Conclusion： The therapy of Shenmai injection combined with sacubitril valsartan for CHF has a good curative effect，and can improve the heart function of patients and reduce the levels of NT-proBNP，sCD40L and PAPP-A.