Abstract：Objective：To observe the clinical effect of Shexiang Baoxin pills combined with metoprolol for stable angina pectoris of coronary heart disease in senile patients. Methods： A total of 133 cases of senile patients with stable angina pectoris of coronary heart disease were selected as the research objects and were divided into the observation group and the control group according to the random number table method，with 68 and 65 cases in each group respectively. Both groups were treated according to the secondary prevention and treatment plan of coronary heart disease， and were given lipidlowering drugs， antiplatelet drugs and anti- myocardial ischemia drugs； the control group was additionally given the oral administration of metoprolol succinate，and the observation group was additionally treated with Shexiang Baoxin pills based on the treatment of the control group. The clinical effects， the onset frequency of angina pectoris， the amount of nitroglycerin usage，and the levels of triglyceride(TG)，total cholesterol(TC)，low-density lipoprotein cholesterol(LDL-C) and high-density lipoprotein cholesterol(HDL-C) in serum in the two groups were observed. Results：The total effective rates of angina pectoris and electrocardiogram were 94.12% and 86.76% respectively in the observation group， and 72.31% and 64.62% respectively in the control group，differences being significant(P＜0.05). Before treatment，there was no significant difference being found in the comparison of the onset frequency of angina pectoris and the amount of nitroglycerin usage between the two groups(P＞0.05). After treatment，the onset frequency of angina pectoris and the amount of nitroglycerin usage in the two groups were decreased when compared with those before treatment(P＜0.05)，and the onset frequency of angina pectoris and the amount of nitroglycerin usage in the observation group were less than those in the control group(P＜ 0.05). Before treatment，there was no significant difference being found in the comparison of the levels of TG，TC，LDL-C and HDL- C between the two groups(P＞0.05). After treatment，the levels of TG，TC and LDL- C in the two groups were lower than those before treatment，and the levels of HDL-C were higher(P＜0.05)；the improvement of the above blood lipid indexes in the observation group was more significant than that in the control group(P＜0.05). Conclusion： The therapy of Shexiang Baoxin pills combined with metoprolol for stable angina pectoris of coronary heart disease in senile patients，and can reduce the onset frequency of angina pectoris and the amount of nitroglycerin usage，and significantly improve the levels of blood lipid.