Abstract： Objective： To observe the clinical effect of modified Sanren tang combined with quadruple therapy for helicobacter pylori(Hp) positive chronic non-atrophic gastritis of spleen-stomach dampness-heat type. Methods：A total of 116 cases of patients with helicobacter pylori positive chronic non- atrophic gastritis were divided into the control group and the observation group according to the random number table method，with 58 cases in each group. The control group was treated with bismuth quadruple therapy，and the observation group was additionally treated with modified Sanren tang based on the treatment of the control group. Both groups were treated for two weeks. The scores of Gastrointestinal Symptom Rating Scale(GSRS)， symptom scores of spleen- stomach dampness- heat syndrome， Hp eradication rates and clinical effects in the two groups were compared. Results：The total effective rate was 94.83% in the observation group and 81.03% in the control group， the difference being significant(P＜0.05). After treatment， GSRS scores in the two groups were decreased when compared with those before treatment(P＜0.05)，and the scores in the observation group was lower than that in the control group(P＜0.05). After treatment，the scores of symptoms such as distending pain in stomach duct，bitter mouth，sticky stool，burning sensation in the stomach cavity and abdomen，torpid intake，and heavy body and fatigue in the two groups were decreased when compared with those before treatment(P＜0.05)，and the above scores in the observation group were lower than those in the control group(P＜0.05). The Hp eradication rate was 91.38% in the observation group and 75.86% in the control group， the difference being significant(P＜0.05). Conclusion： Modified Sanren tang combined with quadruple therapy for helicobacter pylori positive chronic non-atrophic gastritis of spleen-stomach dampness-heat type has a significant curative effect，which can effectively relieve the clinical symptoms of patients and improve the Hp eradication rate.