Abstract：Objective：To observe the clinical effect of Bushen Huoxue tang combined with western medicine on patients with infertility caused by polycystic ovary syndrome(PCOS)， as well as the effect on sex hormones. Methods： A total of 118 cases with infertility caused by PCOS were selected and divided into the control group and the observation group according to different treatment methods， with 59 cases in each group. The control group was treated with clomiphene citrate， and the patients with insulin resistance(IR) were treated with metformin hydrochloride. The observation group was additionally treated with Bushen Huoxue tang based on the treatment of the control group. Both groups were treated for three menstrual cycles. The body mass index(BMI)，waist-hip ratio(WHR) and levels of sex hormones were compared between the two groups before and after treatment. The pregnancy rate and the clinical effects in the two groups were compared. Results：After treatment，the BMI and WHR in both groups were decreased when compared with those before treatment (P＜0.05)， and the BMI and WHR in the observation group were lower than those in the control group(P＜0.05). The pregnancy rate in the observation group was 33.90% ， higher than that of 15.25% in the control group(P＜0.05). The total effective rate was 77.97% in the observation group， higher than that of 52.54% in the control group(P＜0.05). After treatment，the levels of follicle- stimulating hormone(FSH) and estradiol(E2) in both groups were increased when compared with those before treatment(P＜0.05)，and the levels of FSH and E2 in the observation group were higher than those in the control group(P＜0.05)； the levels of luteinizing hormone(LH) and testosterone(T) in both groups were decreased when compared with those before treatment(P＜0.05)，and the two levels in the observation group were lower than those in the control group(P＜0.05). Conclusion： The therapy of Bushen Huoxue tang combined with western medicine can improve clinical effect，reduce body weight and WHR，and improve levels of sex hormone in the treatment of infertility caused by PCOS.