Abstract： Objective： To observe the clinical effect of the therapy of modified Zhuling tang combined with western medicine on the treatment of viral hepatitis type B and cirrhosis complicated with ascites. Methods：A total of 104 patients with viral hepatitis type B and cirrhosis complicated with ascites were selected and divided into the control group and the observation group according to different treatment methods，with 52 cases in each group. The control group was treated with reduced glutathione and furosemide，and the observation group was additionally treated with modified Zhuling tang based on the treatment of the control group. Both groups were treated for two months. The indexes of liver function，Chinese medicine syndrome scores and scores of quality of life were compared between the two groups before and after treatment. The clinical effect and the disappearance time of ascites，abdominal distention and liver pain were compared between the two groups. Results：After treatment，the levels of alanine aminotransferase(ALT)，aspartate aminotransferase(AST) and total bilirubin (TBil) in both groups were decreased when compared with those before treatment(P＜0.05)，and the levels of ALT，AST and TBil in the observation group were lower than those in the control group(P＜0.05). The total effective rate was 90.38% in the observation group，higher than that of 75.00% in the control group(P＜0.05). The disappearance time of ascites，abdominal distention and liver pain in the observation group were shorter than those in the control group(P＜0.05). After treatment，the Chinese medicine syndrome scores in both groups were decreased when compared with those before treatment(P＜0.05)， and the Chinese medicine syndrome score in the observation group was lower than that in the control group(P＜0.05). After treatment，the scores of quality of life in both groups were increased when compared with those before treatment(P＜0.05)， and the scores of quality of life in the observation group were higher than those in the control group(P＜0.05). Conclusion： The therapy of modified Zhuling tang combined with western medicine can improve the therapeutic effect，improve the liver function，promote the disappearance of symptoms and improve the quality of life of patients with viral hepatitis type B and cirrhosis complicated with ascites.