Abstract：Objective：To observe the clinical and nursing effect of L- carnitine combined with Danhong injection in the treatment of senile unstable angina pectoris. Methods：180 elderly patients with unstable angina pectoris treated from March 2017 to March 2019 were randomly divided into two groups. 90 patients in the control group were treated with L-carnitine； 90 cases in the observation group were treated with L-carnitine combined with Danhong injection，and then combined with nursing intervention. The erythrocyte deformation index，erythrocyte aggregation index，plasma viscosity，whole blood low shear reduction viscosity， whole blood high shear reduction viscosity and tumor necrosis factor- α(TNF- α)， Interleukin- 6 (IL- 6)， high sensitivity C- reactive protein(hs- CRP)， high density lipoprotein cholesterol(HDL- C)， low density lipoprotein cholesterol(LDL- C)， total cholesterol(TC)， triglyceride(TG) were compared between the two groups before and after intervention. Results： After the intervention， the hemorheological indexes of the two groups were improved. After the intervention， the erythrocyte deformation index of the observation group was significantly higher than that of the control group， while the erythrocyte aggregation index， plasma viscosity， whole blood low shear reduction viscosity and whole blood high shear reduction viscosity decreased(P＜0.05). After intervention，the inflammatory factors in the two groups were improved，and the TNF-α，IL-6 and hs-CRP of observation group after intervention were significantly lower than those in the control group(P＜0.05). After the intervention，the blood lipid indexes of the two groups were improved. HDL- C in the observation group was significantly higher than those in the control group，while LDL-C，TC and TG were significantly lower than those in the control group(P＜0.05). Conclusion：L-carnitine combined with Danhong injection in the treatment of senile unstable angina pectoris combined with nursing intervention can improve patients' clinical symptoms， effectively remove inflammatory factors，improve blood lipid level and blood flow velocity.