Abstract：Objective：To observe the clinical effect and safety of the therapy of Huayu Zhentong prescription combined with strontium chloride on cancer pain in patients with bone metastases. Methods：A total of 68 bone metastases patients with cancer pain were selected and divided into the observation group and the control group according to the random number table method，with 34 cases in each group. The control group was additionally treated with strontium chloride based on the treatment of oral administration of analgesic medicines， and the observation group was additionally treated with Huayu Zhentong prescription based on the treatment of the control group. Both groups were treated for 14 days. Before and after treatment， the degrees of pain in the two groups were compared by Numerical rating scale(NRS) score， quality of life by karnofsky(KPS) score，and pain markers by levels of endothelin-1 (ET-1) and tumor necrosis factor-α (TNF-α). The clinical effects and incidences of adverse reactions were observed. Results： After treatment， the NRS scores in the two groups were decreased when compared with those before treatment，and the NRS score in the observation group was lower than that in the control group，the difference being significant (P＜0.05). After treatment，the KPS scores in the two groups were increased when compared with those before treatment，and the KPS score in the observation group was higher than that in the control group，differences being significant (P＜0.05). After treatment，the total clinical effective rate was 88.24% in the observation group， higher than that of 73.53% in the control group， the difference being significant(P＜0.05). After treatment，the levels of ET-1 and TNF-α in both groups were decreased when compared with those before treatment，and the above two levels in the observation group were lower than those in the control group，differences being significant (P＜ 0.05). The incidence of adverse reactions was 20.59% in the observation group， and 17.65% in the control group， there v