Abstract：Objective：To observe the clinical effect of Mingmu Dihuang pills combined with sodium hyaluronate eye drops for xerophthalmia. Methods： A total of 82 cases of patients with xerophthalmia were selected and divided into the control group and the study group according to different treatment plans，with 41 cases in each group. The control group was treated with sodium hyaluronate eye drops， and the study group was treated with Mingmu Dihuang pills combined with sodium hyaluronate eye drops. Both groups were treated for eight weeks. The clinical effects in the two groups were observed；the changes in breakup time of tear film and results of tear secretion test before and after treatment in the two groups were compared； the incidences of adverse reactions in the two groups were observed. Results： After treatment， the total effective rate was 73.2% in the control group and 90.2% in the study group，the difference being significant(P＜0.05). After treatment，the breakup time of tear film and the volume of tear secretion in the two groups were increased when compared with those before treatment；in the same course，the breakup time of tear film in the study group was longer than that in the control group，and the volume of tear secretion was more than that in the control group，differences being significant(P＜ 0.05). The total incidence of adverse reactions including retinal blur，hyperemia of conjunctiva and itchy eyes was 22.0% in the study group and 19.5% in the control group， there being no significant difference between the two groups(P＞0.05). Conclusion： The therapy of Mingmu Dihuang pills combined with sodium hyaluronate eye drops for patients with xerophthalmia can improve the curative effect and tear secretion，with high medication safety.