Abstract：Objective：To observe the clinical effect of Xingpi Yang'er granules combined with Chinese medicine umbilical paste for children night sweating. Methods：A total of 100 cases of children with night sweating were selected and divided into the observation group and the control group according to the random number table method，with 50 cases in each group. The control group was given calcium gluconate oral solution and vitamin D drops，and the observation group was additionally treated with Xingpi Yang'er granules combined with Chinese medicine umbilical paste based on the treatment of the control group. Clinical effects，Chinese medicine symptom scores and the disappearance time of clinical symptoms were compared between the two groups. Results：The total effective rate was 96.00% in the observation group，higher than that of 76.00% in the control group，the difference being significant(P＜0.05). Before treatment，there was no significant difference being found in the comparison of each Chinese medicine symptom score and the total scores between the two groups(P＞0.05). After treatment， each Chinese medicine symptom score and the total scores in the two groups were decreased when compared with those before treatment，and the above scores in the observation group were lower than those in the control group，the difference being significant(P＜0.05). The disappearance time of night sweating and restless sleep at night in the observation group was shorter than that in the control group，the difference being significant(P＜0.05). Conclusion：Based on western medicine treatment，the additional use of Xingpi Yang'er granules combined with Chinese medicine umbilical paste has a significant curative effect in treating night sweating，which can harmonize yin and yang，consolidate essence and arrest sweating，improve clinical symptoms of children to a greater extent and promote rehabilitation.