喘可治注射液联合雾化吸入治疗儿童支气管哮喘急性发作期临床研究
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Clinical Study on Chuankezhi Injection Combined with Aerosol Inhalation for Children with Bronchial Asthma in Acute Episode
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    摘要:

    目的:观察喘可治注射液联合雾化吸入治疗儿童支气管哮喘急性发作期的临床疗效。方法:选取100 例支气管哮喘急性发作期患儿,按数字奇偶顺序分为对照组和观察组各50 例。对照组给予雾化吸入治疗,观察组在对照组基础上给予喘可治注射液治疗。比较2 组临床疗效、症状改善时间、肺功能指标及炎症因子水平。结果:观察组临床疗效优于对照组,差异有统计学意义(χ2=4.000,P=0.046)。观察组气喘消失时间、咳嗽缓解时间及哮鸣音消失时间均短于对照组(P<0.05)。治疗后,2 组第1 秒用力呼气容积(FEV1)、用力肺活量(FVC) 及第1 秒用力呼气容积占用力肺活量的百分比(FEV1/FVC) 较治疗前提高(P<0.05);观察组治疗后FEV1、FVC 及FEV1/FVC 水平高于对照组(P<0.05)。治疗后,2 组血清白细胞介素-17(IL-17)、白细胞介素-25(IL-25) 水平低于治疗前(P<0.05);观察组治疗后血清IL-17、IL-25 水平低于对照组(P<0.05)。结论:喘可治注射液联合雾化吸入治疗儿童支气管哮喘急性发作期临床疗效显著,有利于促进患儿症状改善,改善患儿肺功能,减轻机体炎症反应。

    Abstract:

    Abstract:Objective:To observe the clinical effect of Chuankezhi injection combined with aerosol inhalation for children with bronchial asthma in acute episode. Methods: A total of 100 cases of children with bronchial asthma in acute episode were selected and divided into the control group and the observation group according to the digital parity order,with 50 cases in each group. The control group was treated with aerosol inhalation,and the observation group was additionally treated with Chuankezhi injection based on the treatment of the control group. The clinical effects,improvement time of symptoms,lung function indexes and inflammatory factor levels in the two groups were compared. Results: The clinical effect in the observation group was better than that in the control group, the difference being significant(χ2=4.000, P=0.046). The disappearance time of gasp and wheezing rale as well as the remission time of cough in the observation group were shorter than those in the control group(P<0.05). After treatment, forced expiratory volume in the first second(FEV1), forced vital capacity(FVC) and the percentage of forced expiratory volume in the first second to forced vital capacity(FEV1/FVC) in the two groups were increased when compared with those before treatment(P<0.05);the levels of FEV1,FVC and FEV1/FVC in the observation group were higher than those in the control group(P<0.05). After treatment,the levels of interleukin-17(IL-17) and interleukin-25(IL-25) in serum in the two groups were lower than those before treatment(P<0.05);the levels of IL-17 and IL-25 in serum in the observation group were lower than those in the control group(P<0.05). Conclusion:The therapy of Chuankezhi injection combined with aerosol inhalation for children with bronchial asthma in acute episode has a significant clinical effect,and can improve the symptoms and lung function of children,and reduce the inflammatory responses of the body.

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吴小波.喘可治注射液联合雾化吸入治疗儿童支气管哮喘急性发作期临床研究[J].新中医,2022,54(3):116-119

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  • 在线发布日期: 2022-02-14
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