Abstract：Objective：To observe the clinical effect of Chuankezhi injection combined with aerosol inhalation for children with bronchial asthma in acute episode. Methods： A total of 100 cases of children with bronchial asthma in acute episode were selected and divided into the control group and the observation group according to the digital parity order，with 50 cases in each group. The control group was treated with aerosol inhalation，and the observation group was additionally treated with Chuankezhi injection based on the treatment of the control group. The clinical effects，improvement time of symptoms，lung function indexes and inflammatory factor levels in the two groups were compared. Results： The clinical effect in the observation group was better than that in the control group， the difference being significant(χ2=4.000， P=0.046). The disappearance time of gasp and wheezing rale as well as the remission time of cough in the observation group were shorter than those in the control group(P＜0.05). After treatment， forced expiratory volume in the first second(FEV1)， forced vital capacity(FVC) and the percentage of forced expiratory volume in the first second to forced vital capacity(FEV1/FVC) in the two groups were increased when compared with those before treatment(P＜0.05)；the levels of FEV1，FVC and FEV1/FVC in the observation group were higher than those in the control group(P＜0.05). After treatment，the levels of interleukin-17(IL-17) and interleukin-25(IL-25) in serum in the two groups were lower than those before treatment(P＜0.05)；the levels of IL-17 and IL-25 in serum in the observation group were lower than those in the control group(P＜0.05). Conclusion：The therapy of Chuankezhi injection combined with aerosol inhalation for children with bronchial asthma in acute episode has a significant clinical effect，and can improve the symptoms and lung function of children，and reduce the inflammatory responses of the body.