Abstract：Objective：To observe the effect of the therapy of oral administration of Bushen Qiangji tang combined with acupuncture and moxibustion on joint range of motion and clinical effects in patients with ankylosing spondylitis. Methods：A total of 64 patients with ankylosing spondylitis were selected and divided into the control group and the observation group according to the random number table method，with 32 cases in each group. The control group was treated with acupuncture and moxibustion，and the observation group was additionally treated with Bushen Qiangji tang based on the treatment of the control group. The clinical effects，joint range of motion and levels of inflammatory factors in the two groups were observed. Results：After treatment，the total effective rate was 93.75% in the observation group，higher than that of 71.88% in the control group(P＜0.05). After treatment，the Schober test of spine range of motion and differences of chest range of motion during breathing in the two groups were increased when compared with those before treatment(P＜0.05)，and the distance between jaw and sternal manubrium，distance between finger and ground as well as distance between occipital bone and wall，and the levels of interleukin-6(IL-6)，tumor necrosis factor-α(TNF-α) and C-reactive protein(CRP) were decreased(P＜ 0.05)；after treatment，the Schober test and differences of chest range of motion during breathing in the observation group were higher than those in the control group(P＜0.05)， and the distance between jaw and sternal manubrium， distance between finger and ground as well as distance between occipital bone and wall，and the levels of IL- 6，TNF- α and CRP were lower(P＜0.05). Conclusion：The therapy of oral administration of Bushen Qiangji tang combined with acupuncture and moxibustion can significantly enhance the clinical effect of patients with ankylosing spondylitis，improve their joint range of motion and reduce the levels of inflammatory factors.