解毒固本汤联合西药治疗溃疡性结肠炎的疗效 及对肠道菌群、免疫功能的影响
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R574.62

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Curative Effect of Jiedu Guben Tang Combined with Western Medicine for Ulcerative Colitis and Its Effect on Intestinal Flora and Immune Function
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    摘要:

    目的:观察解毒固本汤联合西药治疗溃疡性结肠炎的疗效以及对肠道菌群、免疫功能的影响。方法:选取120 例溃疡性结肠炎患者,按随机数字表法分为观察组及对照组各60 例。对照组采用常规西药治疗,观察组在对照组基础上加用解毒固本汤治疗,2 组均连续治疗6 周。观察2 组临床疗效,比较2 组治疗前后中医证候评分、肠道菌群(大肠杆菌、乳酸杆菌、双歧杆菌) 及血清T 淋巴细胞亚群数值(CD3+、CD4+、CD4+/CD8+) 变化。结果:治疗后,观察组中医证候(11.77±2.31) 分,对照组中医证候(16.87±3.05) 分,差异有统计学意义(P<0.05)。治疗后,观察组临床疗效总有效率为96.67%,对照组临床疗效总有效率为85.00%,2 组比较,差异有统计学意义(P<0.05)。治疗后,2 组大肠杆菌水平均较治疗前下降,乳酸菌、双歧杆菌水平均较治疗前上升,差异均有统计学意义(P<0.05);治疗后,观察组乳酸杆菌、双歧杆菌水平均高于对照组,大肠杆菌水平低于对照组,差异均有统计学意义(P<0.05)。治疗后,2 组CD3+、CD4+及CD4+/CD8+水平均较治疗前上升(P<0.05);治疗后,观察组上述3 项水平均高于对照组,差异均有统计学意义(P<0.05)。结论:解毒固本汤联合西药可有效缓解溃疡性结肠炎患者腹痛、腹泻等症状,改善肠道菌群,减轻炎症情况。

    Abstract:

    Abstract:Objective:To observe the curative effect of Jiedu Guben tang combined with western medicine for ulcerative colitis and its effect on intestinal flora and immune function. Methods:A total of 120 cases of patients with ulcerative colitis were selected and divided into the observation group and the control group according to the random number table method, with 60 cases in each group. The control group was treated with routine western medicine,and the observation group was additionally treated with Jiedu Guben tang based on the treatment of the control group. Both groups were treated for six weeks. The clinical effects in the two groups were observed. Before and after treatment,the changes in Chinese medicine syndrome scores, intestinal flora including escherichia coli, lactobacillus and bifidobacterium as well as indexes of T lymphocyte subsets in serum including CD3 + , CD4 + and CD4 +/CD8 + in the two groups were compared. Results: After treatment,the Chinese medicine syndrome score was 11.77±2.31 points in the observation group and 16.87±3.05 points in the control group, the difference being significant(P<0.05). After treatment, the total effective rate of clinical effect was 96.67% in the observation group and 85.00% in the control group,the difference being significant(P<0.05). After treatment, the numbers of escherichia coli in the two groups were decreased when compared with those before treatment, and the numbers of lactobacillus and bifidobacterium were increased, differences being significant(P<0.05); the numbers of lactobacillus and bifidobacterium in the observation group were greater than those in the control group,and the number of escherichia coli was smaller,differences being significant(P<0.05). After treatment,the levels of CD3 +,CD4 + and CD4 +/ CD8+ in the two groups were increased when compared with those before treatment,differences being significant(P<0.05); the levels of the above three items in the observation group were higher than those in the control group,differences being significant(P<0.05). Conclusion: The therapy of Jiedu Guben tang combined with western medicine for patients with ulcerative colitis can effectively alleviate their symptoms of abdominal pain and diarrhea,improve intestinal flora and relieve inflammation.

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王垚,王芳,王雪.解毒固本汤联合西药治疗溃疡性结肠炎的疗效 及对肠道菌群、免疫功能的影响[J].新中医,2022,54(3):80-84

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  • 在线发布日期: 2022-02-14
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