Abstract： Objective： To observe the clinical effect of the therapy of Anshen Bunao liquid combined with western medicine on insomnia of bipolar disorder in maintenance period. Methods：A total of 104 clinical data of patients with insomnia of bipolar disorder in maintenance period were retrospectively selected and divided into the control group and the observation group according to the treatment methods in the data， with 52 cases in each group. The control group was treated with routine western medicine， and the observation group was additionally treated with Anshen Bunao liquid based on the treatment of the control group. Before and after treatment，the negative emotions evaluated by Hamilton Anxiety Rating Scale (HAMA) and Hamilton Rating Scale for Depression(HAMD)， scores of Pittsburgh Sleep Quality Index(PSQI) and related indexes of sleep status in the two groups were compared. The clinical effects in the two groups were evaluated， and the adverse reactions were observed. Results：The total effective rate was 98.08% in the observation group，higher than that of 82.69% in the control group，the difference being significant(P＜0.05). After treatment，the scores of HAMD，HAMA and PSQI in the two groups were decreased when compared with those before treatment， and the above scores in the observation group were lower than those in the control group，differences being significant(P＜0.05). After treatment，the total sleep time and sleep efficiency in the two groups were increased when compared with those before treatment，and the numbers of awakening at night were smaller(P＜0.05)；the total sleep time and sleep efficiency in the observation group were higher than those in the control group，and the number of awakening at night was smaller(P＜0.05). The incidence of adverse reactions was 7.69% in the observation group， and was 13.46% in the control group， there being no significance in the difference(χ 2=0.915，P=0.339). Conclusion：The therapy of Anshen Bunao liquid assisting western medicine has a definite effect on patients with insomnia of bipolar disorder in maintenance period，which can significantly improve the sleep quality， depression and anxiety of patients.