调脂汤对急性脑梗死患者血液流变学及颈动脉粥样硬化斑块的影响
DOI:
作者:
作者单位:

作者简介:

通讯作者:

中图分类号:

R743.3

基金项目:


Effect of Tiaozhi Tang on Hemorheology and Carotid Atherosclerotic Plaque in Patients with Acute Cerebral Infarction
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    目的:观察调脂汤对急性脑梗死患者血液流变学及颈动脉粥样硬化斑块的影响。方法:选取92 例急性脑梗死患者,按随机数字表法分为对照组和观察组各46 例。对照组给予常规西药治疗,观察组在对照组基础上加用调脂汤治疗。评价2 组临床疗效,比较2 组治疗前后血清白细胞介素-6 (IL-6)、肿瘤坏死因子(TNF-α)、超敏C-反应蛋白(hs-CRP)、血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C) 水平,检测血液流变学指标(全血高切黏度、全血低切黏度、血液黏度) 及颈动脉超声检查指标[颈动脉内径、舒张末期流速、收缩期峰值流速、颈动脉内中膜厚度(IMT)、Crouse 斑块积分]。结果:观察组总有效率为78.26%,高于对照组58.70%,差异有统计学意义(P<0.05)。治疗后,2 组血清IL-6、TNF-α、hs-CRP、TG、TC、LDL-C 水平较治疗前均明显降低(P<0.05),且观察组明显低于对照组(P<0.05);2 组血清HDL-C 水平较治疗前均明显升高(P<0.05),且观察组明显高于对照组(P<0.05)。治疗后,2 组全血高切黏度、全血低切黏度、血液黏度较治疗前均明显降低(P<0.05),且观察组明显低于对照组(P<0.05)。治疗后,2 组颈动脉内径较治疗前均明显升高(P<0.05),且观察组明显高于对照组(P<0.05);2 组舒张末期流速、收缩期峰值流速、IMT、Crouse 斑块积分较治疗前均明显降低(P<0.05),且观察组明显低于对照组(P<0.05)。结论:调脂汤治疗急性脑梗死疗效显著,能够有效降低炎症反应,调节血脂水平,改善血液流变学指标,缩小颈动脉粥样硬化斑块面积。

    Abstract:

    Abstract:Objective:To observe the effect of Tiaozhi tang on hemorheology and carotid atherosclerotic plaque in patients with acute cerebral infarction. Methods: A total of 92 cases of patients with acute cerebral infarction were selected and divided into the control group and the observation group according to the random number table method, with 46 cases in each group. The control group was treated with routine western medicine,and the observation group was additionally treated with Tiaozhi tang based on the treatment of the control group. The clinical effects in the two groups were evaluated. Before and after treatment,the levels of interleukin-6(IL-6),tumor necrosis factor(TNF-α),hypersensitive C-reactive protein(hs- CRP) , total cholesterol(TC) , triglyceride(TG) , high- density lipoprotein cholesterol(HDL- C) and low- density lipoprotein cholesterol(LDL-C) in serum in the two groups were compared. The changes in hemorheology indexes including whole blood high shear viscosity,whole blood low shear viscosity and blood viscosity as well as the indexes of carotid ultrasonography including carotid arterial diameter, end diastolic velocity, peak systolic velocity, carotid intima- media thickness(IMT) and Crouse plaque scores were detected. Results:The total effective rate was 78.26% in the observation group,higher than that of 58.70% in the control group, the difference being significant(P<0.05). After treatment, the levels of IL- 6, TNF- α, hs- CRP,TG,TC and LDL- C in serum in the two groups were significantly decreased when compared with those before treatment(P<0.05),and the above levels in the observation group were significantly lower than those in the control group(P< 0.05);the levels of serum HDL-C in the two groups were significantly increased when compared with those before treatment (P<0.05), and the level in the observation group was significantly higher than that in the control group(P<0.05). After treatment,whole blood high shear viscosity,whole blood low shear viscosity and blood viscosity in the two groups were significantly decreased when compared with those before treatment(P<0.05), and the above indexes in the observation group were significantly lower than those in the control group(P<0.05). After treatment,the carotid arterial diameters in the two groups were significantly increased when compared with those before treatment(P<0.05), and the one in the observation group was significantly higher than that in the control group(P<0.05). The end diastolic velocity, peak systolic velocity,IMT and Crouse plaque scores in the two groups were significantly decreased when compared with those before treatment(P<0.05),and the above indexes in the observation group were significantly lower than those in the control group (P<0.05). Conclusion:The application of Tiaozhi tang for acute cerebral infarction has a significant curative effect,and can effectively reduce inflammatory responses,regulate blood lipid levels,improve hemorheology indexes and reduce the area of carotid atherosclerotic plaque.

    参考文献
    相似文献
    引证文献
引用本文

苗亚南.调脂汤对急性脑梗死患者血液流变学及颈动脉粥样硬化斑块的影响[J].新中医,2022,54(3):56-60

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期: 2022-02-14
  • 出版日期: