Abstract：At present， the pathogenesis of psoriasis is not clear. With the deepening of mechanism research， biological agents， as a new method of treatment， are gradually applied to clinic with their unique advantages. Among them， targeted drugs targeting co- inhibitory receptors have achieved remarkable curative effects in the treatment of a variety of diseases. Traditional Chinese medicine has significant advantages in the treatment of psoriasis. Its effect on the human body has the characteristics of multi- channel and multi- target. This paper reviews the research progress of co- inhibitory receptors in psoriasis， in order to provide basis for the targeted treatment of co-inhibitory receptors in psoriasis， and provide new ideas for the research and application of traditional Chinese medicine in the treatment of psoriasis.