Abstract： Objective： To investigate the effects of naringin on inflammatory pathway and inflammatory necrosis during cerebral infarction in Wistar rats， and to understand the molecular mechanism of naringin in improving cerebral infarction. Methods： Wistar rats were randomly divided into sham operation group， simple model group and naringin group.After naringin intervention， the changes of neurological function and infarct area of brain tissue were detected. After naringin intervention， lactate dehydrogenase and inflammatory related factor tumor necrosis factor- α in serum and level of interleukin- 1β of Wistar rats were detected.In addition，the effect of naringin on the activity of human brain glial cells(HEB cells) after hypoxia injury was detected in vitro，and the expression of inflammatory necrosis related factors and high mobility group box1(HMGB1)/Toll-link receptosrs 4(TLR4)/nuclear factor-κB(NF-κB) were detected. Results：After administration of naringin to Wistar rats with cerebral infarction， the nerve energy injury was significantly improved， the score of nerve function injury was significantly lower than that of the simple model group(P＜0.05)，and the cerebral surface infarct area was significantly lower than that of the simple model group.Serum tumor necrosis factor- α and interleukin- 1β and the levels of and lactate dehydrogenase in cerebral infarction rats treated with naringin decreased significantly. At the cellular level， naringin has an obvious protective effect on cells in hypoxic environment，and the cell activity is significantly higher than that in hypoxia group. At the molecular level， Western blotting results show that naringin can inhibit HMGB1/TLR4/NF- κB. Conclusion：Naringin can inhibit HMGB1/TLR4/NF-κB pathway down regulates the expression of inflammatory and necrosis related factors，which has a certain protective effect on cerebral infarction injury.