Abstract： Objective： To observe the clinical effect of jiaogulanzongdai pian on the treatment of hyperlipidemia in pregnancy. Methods：A total of 156 pregnant patients with hyperlipidemia were selected and divided into the control group and the observation group according to the random number table method，with 78 cases in each group. The control group was intervened with nutritional diet， and the observation group was additionally given jiaogulanzongdai pian based on the treatment of the control group. The two groups were treated continuously for eight weeks. The levels of blood lipid and clinical effect in the two groups were compared，and the adverse reactions during the course of treatment were recorded. Results： The total effective rate was 94.87% in the observation group and 83.33% in the control group，the difference being significant (P＜0.05). Before treatment， there was no significant difference in the comparison of the levels of triglyceride(TG)， total cholesterol(TC)，low density lipoprotein cholesterol(LDL-C) and high density lipoprotein cholesterol(HDL-C) between the two groups(P＞0.05). After treatment， the levels of TG， TC and LDL- C in both groups were decreased when compared with those before treatment(P＜0.05)，while the HDL-C levels were increased(P＜0.05). The levels of TG，TC and LDL-C in the observation group were lower than those in the control group(P＜0.05)，and the HDL-C level was higher(P＜0.05). During the treatment， there was no abnormality in hematuria routine， liver and kidney function and other indicators in both groups. Conclusion： Jiaogulanzongdai pian has a significant effect on the treatment of hyperlipidemia in pregnancy， which can effectively reduce the level of blood lipid，with great safety.