Abstract： Objective： To observe the clinical effect of ginkgo diterpene lactone glucamine combined with clopidogrel bisulfate for ischemic stroke. Methods：A total of 74 cases of patients with ischemic stroke were randomly divided into the study group and the control group according to the randomized double- blind method， with 37 cases in each group. The control group was treated with clopidogrel bisulfate， and the study group was additionally treated with ginkgo diterpene lactone glucamine based on the treatment of the control group. Both groups were treated for two weeks. The clinical effects and incidences of adverse reactions in the two groups were compared. Before and after treatment，the levels of interleukin-8 (IL- 8)， tumor necrosis factor- α(TNF- α)， hypersensitive C- reactive protein(hs- CRP) and fibrinogen(FIB) as well as the activated partial thromboplastin time(APTT) in the two groups were compared； the degree of neurological deficit and the quality of life in the two groups were evaluated by National Institutes of Health Stroke Scale(NIHSS) and Quality of Life Scale (QOL). Results：The total effective rate was 91.89% in the study group，higher than that of 72.97% in the control group(P＜ 0.05). After treatment，the levels of IL-8，TNF-α，hs-CRP and FIB in the two groups were decreased when compared with those before treatment(P＜0.05)，and APTT was prolonged(P＜0.05)；the levels of IL- 8，TNF- α，hs- CRP and FIB in the study group were lower than those in the control group(P＜0.05)，and the APTT was longer(P＜0.05). After treatment，the NIHSS scores in the two groups were decreased when compared with those before treatment(P＜0.05)，and the scores of appetite，sleep，mentality and daily life in the two groups were increased(P＜0.05)；the NIHSS score in the study group was lower than that in the control group(P＜0.05)， and the scores of appetite， sleep， mentality and daily life were higher(P＜ 0.05). The incidence of adverse reactions was 10.81% in the study group and 16.22% in the control group，there being no significant difference between the two groups(P＞0.05). Conclusion： The therapy of ginkgo diterpene lactone glucamine combined with clopidogrel bisulfate for ischemic stroke can inhibit systemic inflammatory response and improve coagulation function，neurological function and quality of life of patients，with good safety.