补中益气汤、葛根芩连汤联合西药治疗慢性结肠炎临床研究
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R574.62

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Clinical Study on Buzhong Yiqi Tang and Gegen Qinlian Tang Combined with Western Medicine for Chronic Colitis
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    摘要:

    目的:观察补中益气汤、葛根芩连汤联合西药治疗慢性结肠炎的临床疗效。方法:选取92 例慢性结肠炎患者,根据随机数字表法分为对照组和观察组,每组46 例。对照组给予西药治疗,观察组在对照组基础上给予补中益气汤联合葛根芩连汤治疗,2 组均连续治疗3 个月。比较2 组治疗前后症状评分及炎症因子水平;比较2 组临床疗效及不良反应发生率。结果:治疗后,2 组腹泻、脓血便、腹痛腹胀、里急后重、发热、肛门灼热评分均较治疗前降低(P<0.05),观察组腹泻、脓血便、腹痛腹胀、里急后重、发热、肛门灼热评分均低于对照组(P<0.05)。治疗后,2 组血清C-反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α) 水平均较治疗前降低(P<0.05),观察组血清CRP、IL-6、TNF-α 水平均低于对照组(P<0.05)。经秩和检验,观察组临床疗效优于对照组(P<0.05)。2 组恶心呕吐、头痛、皮疹、失眠发生率比较,差异均无统计学意义(P>0.05)。结论:补中益气汤、葛根芩连汤联合西药治疗慢性结肠炎,可有效改善患者的临床症状,减轻炎症反应,且安全性好。

    Abstract:

    Abstract:Objective:To observe the clinical effect of the therapy of Buzhong Yiqi tang and Gegen Qinlian tang combined with western medicine on the treatment of chronic colitis. Methods:A total of 92 patients with chronic colitis were selected and divided into the control group and the observation group according to the random number table method,with 46 cases in each group. The control group was given western medicine for treatment, and the observation group was additionally treated with Buzhong Yiqi tang and Gegen Qinlian tang based on the treatment of the control group. Both groups were given continuous treatment for three months. The symptom scores and levels of inflammatory factor were compared between the two groups before and after treatment. The clinical effect and incidence of adverse reactions were compared between the two groups. Results:After treatment,the scores of symptoms,including diarrhea,stools containing pus and blood,abdominal pain and distention,tenesmus,fever and anal burning in both groups,were decreased when compared with those before treatment(P<0.05),and the above scores of symptoms in the observation group were lower than those in the control group (P<0.05). After treatment,the levels of serum C- reactive protein(CRP),interleukin- 6(IL- 6) and tumor necrosis factor- α (TNF- α) in both groups were decreased when compared with those before treatment(P<0.05), and the levels of serum CRP,IL-6 and TNF-α in the observation group were lower than those in the control group(P<0.05). By rank sum test,the clinical effect in the observation group was better than that in the control group(P<0.05). There was no significant difference in the incidence of nausea and vomiting, headache, rash and insomnia between the two groups(P>0.05). Conclusion: The therapy of Buzhong Yiqi tang and Gegen Qinlian tang combined with western medicine in the treatment of chronic colitis,can effectively lessen the clinical symptoms of patients and reduce inflammation reactions,with great safety.

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张璐,胡杰.补中益气汤、葛根芩连汤联合西药治疗慢性结肠炎临床研究[J].新中医,2022,54(2):5-8

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  • 在线发布日期: 2022-01-22
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