Abstract： Objective： To observe the curative effect of the therapy of finger pressing combined with balance therapy training on children with cerebral palsy of hypotonia type. Methods：A total of 180 children with cerebral palsy of hypotonia type were selected and divided into the control group and the observation group according to the random number table method，with 90 cases in each group. The control group was given balance therapy，and the observation group was given finger pressing combined with balance therapy. The clinical effects in the two groups were observed. Before and after treatment，the scores of Gross Motor Function Measure(GMFM)，the changes of levels of serum brain-derived neurotrophic factor(BDNF)，myelin basic protein(MBP) and neuron- specific enolase(NSE) and the changes of scores of Barthel Index(BI) and Pediatric Quality of Life InventoryTM(PedsQLTM) in the two groups were compared. Results：The total effective rate was 97.78% in the observation group，higher than that of 86.67% in the control group，the difference being significant(P＜0.05). After treatment，the scores of function of areas A，B，C，D and E of gross motor in the two groups were increased when compared with those before treatment， and the above five scores in the observation group were higher than those in the control group， differences being significant(P＜0.05). After treatment， the levels of serum BDNF in the two groups were increased when compared with those before treatment，and the levels of MBP and NSE were decreased；the level of serum BDNF in the observation group was higher than that in the control group， and the levels of MBP and NSE were lower， differences being significant(P＜0.05). After treatment，the scores of BI and PedsQLTM in both groups were increased when compared with those before treatment， the difference being significant(P＜0.05)； the scores of BI and PedsQLTM in the observation group were higher than those in the control group， differences being significant(P＜0.05). Conclusion： The therapy of finger pressing combined with balance therapy training can effectively recover the muscle strength，improve the damage degree of brain，activity ability of daily living and quality of life in children with cerebral palsy of hypotonia type.