Abstract： Objective： To observe the clinical effect of Qiwei Zhige prescription combined with CF chemotherapy for advanced esophageal squamous cell carcinoma of qi deficiency with phlegm stasis type and its effect on adverse reactions. Methods：A total of 100 cases of patients with advanced esophageal squamous cell carcinoma were selected and divided into the observation group and the control group by coin- tossing method，with 50 cases in each group. The control group was given CF chemotherapy scheme，and the observation group was additionally given modified Qiwei Zhige prescription based on the treatment of the control group. Both groups were treated for two cycles， with 21 days being a cycle. Changes in indexes of immune function， degree of adverse reactions， scores of quality of life(QOL) in cancer patients， and disease control rates were compared between the two groups. Results：After treatment，CD4 + and CD4 +/CD8 + in the two groups were decreased when compared with those before treatment，and CD4+ and CD4+/CD8+ in the observation group were higher than those in the control group，differences being significant(P＜0.05). After treatment，myelosuppression ［white blood cell count(WBC)，platelet(BPC)] as well as degree of adverse reactions including nausea，vomiting and diarrhea in the observation group were lower than those in the control group，differences being significant(P＜0.05). After treatment，appetite，mental status，pain degree，effects of adverse reactions on life，attitude to treatment in QOL in the two groups were decreased when compared with those before treatment，and the above five scores in the control group were lower than those in the observation group， differences being significant(P＜0.05). The disease control rate was 56.00% in the control group and 68.00% in the observation group，the difference being significant(P＜0.05). Conclusion：Qiwei Zhige prescription combined with CF chemotherapy has a significant curative effect on patients with advanced esophageal squamous cell carcinoma， which can relieve adverse reactions of chemotherapy，and improve immune function and quality of life.