Abstract： Objective： To study the effects of curcumin analogue L50H8 on proliferation， invasion and apoptosis of ovarian cancer OVCAR3 cells and explore its mechanism. Methods：The effect of L50H8 on cell proliferation was detected by MTT assay； Annexin V/PI double staining flow cytometry was used to detect the effect of L50H8 on apoptosis.The effect of L50H8 on cell invasion was detected by Transwell method.To explore the mechanism of L50H8 affecting cell invasion by Western blot. To detect its effect on the expression of extracellular matrix metalloproteinase inducer(CD147)， matrix metalloproteinase 2(MMP2)， MMP9 and vascular endothelial growth factor(VEGF).To explore the mechanism of L50H8 inducing cell apoptosis， its effects on the expression of endoplasmic reticulum stress(ERS) promoter glucose regulated protein 78(GRP78) and preapoptotic factor C/EBP-homologous protein(CHOP) were detected. Results ： L50H8 could significantly inhibit the proliferation of OVCAR3 cells， and the IC50 at 24 h was(3.08 ± 0.08) μmol/L. L50H8 can induce apoptosis of OVCAR3 cells，and its apoptosis inducing effect is stronger than curcumin. Western blot showed that L50H8 can down regulate the expression of CD147，MMP2，MMP9 and VEGF，and up regulate the expression of GRP78 and CHOP. Conclusion： L50H8 can significantly inhibit the proliferation of OVCAR3 cells， reduce cell invasion by down regulating CD147，MMP2，MMP9 and VEGF，and induce ERS induced apoptosis.