复明胶囊联合甲钴胺治疗糖尿病视网膜病变临床研究
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R587.2

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Clinical Study on Fuming Capsules Combined with Mecobalamine for Diabetic Retinopathy
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    摘要:

    目的:观察复明胶囊联合甲钴胺治疗糖尿病视网膜病变的临床疗效及对血糖、视力及炎性因子的影响。方法:选取80 例糖尿病视网膜病变患者临床资料进行回顾性分析,根据治疗方式分为对照组和观察组各40 例。2 组均给予降糖、降压、调脂、糖尿病饮食、运动指导等常规治疗,对照组给予甲钴胺片口服,观察组在对照组基础上加用复明胶囊口服。比较2 组临床疗效及治疗前后血糖、视力、炎性因子水平、中医症状评分。结果:观察组总有效率为92.50%,高于对照组72.50%,差异有统计学意义(P<0.05)。治疗后,2 组空腹血糖(FBG)、餐后2 h 血糖(P2hBG)、糖化血红蛋白(HbA1c) 水平较治疗前降低(P<0.05)。治疗后,2 组血清白细胞介素-1β(IL-1β)、细胞间黏附分子-1(ICAM-1)、肿瘤坏死因子-α(TNF-α)、血管内皮生长因子(VEGF)水平较治疗前均降低,且观察组血清IL-1β、ICAM-1、TNF-α、VEGF 水平均低于对照组,差异均有统计学意义(P<0.05)。治疗后,2 组各项中医症状评分较治疗前降低,且观察组各项中医症状评分低于对照组,差异均有统计学意义(P<0.05)。结论:复明胶囊联合甲钴胺治疗糖尿病视网膜病变可有效降低患者炎性反应,改善视力,提高临床疗效。

    Abstract:

    Abstract: Objective: To observe the clinical effect of Fuming capsules combined with mecobalamine for diabetic retinopathy and its effect on blood glucose,acuity and inflammatory factors. Methods:A total of 80 cases of patients with diabetic retinopathy were given a retrospective analysis on their clinical data, and divided into the control group and the observation group according to their treatment methods, with 40 cases in each group. Both groups were given routine treatment including reducing blood glucose,lowering blood pressure,regulating lipid,diabetic diet and exercise guidance; the control group was given oral administration of mecobalamine tablets,and the observation group was additionally treated with Fuming capsules based on the treatment of the control group. The blood glucose,acuity,levels of inflammatory factors and Chinese medicine symptom scores before and after treatment as well as the clinical effects in the two groups were compared. Results:The total effective rate was 92.50% in the observation group,higher than that of 72.50% in the control group,the difference being significant(P<0.05). After treatment,the levels of fasting blood glucose(FBG),postprandial 2h blood glucose(P2hBG) and glycated hemoglobin A1c(HbA1c) in the two groups were decreased when compared with those before treatment(P<0.05). After treatment,the levels of interleukin-1β(IL-1β),intercellular adhesion molecule-1(ICAM-1), tumor necrosis factor- α(TNF- α) and vascular endothelial growth factor(VEGF) in serum in the two groups were decreased when compared with those before treatment, and the levels of IL- 1β、ICAM- 1, TNF- α and VEGF in serum in the observation group were lower than those in the control group,differences being significant(P<0.05). After treatment,the Chinese medicine symptom scores in the two groups were decreased when compared with those before treatment,and the Chinese medicine symptom scores in the observation group were lower than those in the control group,differences being significant(P<0.05). Conclusion: Fuming capsules combined with mecobalamine for diabetic retinopathy can effectively reduce inflammatory responses,and improve acuity and curative observation.

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季美霞,刘坚,曾誌復,朱向盈.复明胶囊联合甲钴胺治疗糖尿病视网膜病变临床研究[J].新中医,2022,54(1):85-88

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  • 在线发布日期: 2022-01-10
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