Abstract：Objective：To observe the clinical effect of Yangfei Yishen granules combined with routine therapy for chronic obstructive pulmonary disease(COPD) at stable stage and its effect on quality of life and immune function. Methods：A total of 60 cases of patients with COPD at stable stage were selected and divided into the control group and the treatment group according to the random number table method，with 30 cases in each group. The control group was given routine treatment according to relevant guidelines， and the treatment group was additionally given the oral administration of Yangfei Yishen granules based on the treatment of the control group. Both groups were observed and treated for 12 weeks. Before and after treatment， the changes in Chinese medicine syndrome scores， modified Medical Research Council(mMRC)， COPD Assessment Test(CAT)，cytokines including monocyte chemoattractant protein(MCP-1)，γ-interferon(IFN-γ)，interleukin-4 (IL-4) and interleukin-10(IL-10) in serum，forced vital capacity(FVC)，the forced expiratory volume in one second(FEV1) and the ratio of forced expiratory volume in one second to forced vital capacity(FEV1/FVC) in the two groups were compared. The clinical effects in the two groups were observed. Results： After treatment， the scores of coughing， wheezing， chest oppression， shortness of breath， lack of strength and cyanosis in the two groups were decreased when compared with those before treatment；the scores of coughing and chest oppression in the treatment group were lower than those in the control group，differences being significant(P＜0.01). After treatment，the scores of mMRC and CAT in the two groups were decreased when compared with those before treatment，and the above two scores in the treatment group were lower than those in the control group， differences being significant(P＜0.05). After treatment， the levels of FVC and FEV1 in the treatment group were lower than those in the control group， but the difference were not statistically significant(P＞0.05)， and the level of FEV1/FVC was higher(P＜0.05). After treatment， the levels of MCP- 1 and IFN- γ in the two groups were decreased when compared with those before treatment，and the levels of IL-4 were increased，differences being significant (P＜0.05)；the levels of MCP-1 and IFN-γ in the treatment group were lower than those in the control group，and the level of IL-10 was higher，differences being significant(P＜0.05). The total effective rate was 90.00% in the treatment group and 66.67% in the control group，the difference being significant(P＜0.05). Conclusion：The therapy of Yangfei Yishen granules combined with routine therapy for COPD at stable stage can improve dyspnea and delay the disease progression.