Abstract：“Guowei Class” is one of the characteristic class types explored by Guangzhou University of Chinese Medicine in the innovation of Chinese medicine professional talent training mode. In order to uphold the medical education concept of "early，multiple and repeated clinical practice"，its clinical courses adopt the integrated small-class teaching mode of "classroom teaching plus bedside teaching(BT) plus problem based learning(PBL) teaching". As a basic discipline of clinical medicine， internal medicine covers a wide range of aspects and contains rich knowledge. If the integrated small- class teaching model is adopted in teaching internal medicine，certain results can be achieved. This paper discusses the application of integrated small- class teaching mode in internal medicine teaching of “Guowei Class”， so as to provide reference in clinical teaching.