Abstract： Objective： To observe the preventive effect of Shuxuetong injection combined with external application of self-made Binghuang powder on lower extremity deep venous thrombosis(DVT) after major orthopedic surgery. Methods：A total of 160 cases of patients who received major orthopedic surgery were randomly divided into the control group and the observation group， with 80 cases in each group. The control group was treated with routine prevention and treatment including aspirin tablets and low molecular weight heparin sodium，and the observation group was additionally treated with intravenous infusion of Shuxuetong injection and external application of Binghuang powder based on the treatment of the control group. The incidence of DVT ， circumference differences between thigh and calf ， coagulation function including D- dimer(D- D)，prothrombin time(PT)，fibrinogen(Fib) and activated partial thromboplastin time(APTT)，blood flow indexes including plasma viscosity and whole blood viscosity at low and high shear rates， levels of inflammatory factors including C- reactive protein(CRP)，tumor necrosis factor- α(TNF- α)，interleukin- 6(IL- 6) and interleukin- 8(IL- 8) as well as adverse reactions in the two groups were observed and compared. Results： The incidence of DVT was 15.00% in the observation group and was 28.75% in the control group，the difference being significant(P＜0.05). On the first day after operation，there was no significant difference being found in the comparison of differences of the thigh and calf between the two groups(P＞ 0.05)； on the 14th days after operation， the above circumference differences in the two groups were reduced when compared with those on the first day after operation(P＜0.05)，and the difference in the observation group was smaller than that in the control group(P＜0.05). On the first day after operation， there was no significant difference being found in the comparison of levels of D- D，PT，Fib and APTT between the two groups(P＞0.05)；on the 14th day after operation，the above four levels in the two groups were deceased when compared with those on the first day after operation(P＜0.05)，and the levels in the observation group were lower than those in the control group(P＜0.05). On the first day after operation，there was no significant difference being found in the comparison of levels of CRP，TNF-α，IL-6 and IL-8 between the two groups (P＞0.05)；on the 14th day after operation，the above four levels in the two groups were decreased when compared with those on the first day after operation(P＜0.05)，and the levels in the observation group were lower than those in the control group(P＜0.05). On the first day after operation，there was no significant difference being found in the comparison of plasma viscosity and whole blood viscosity at low and high shear rates between the two groups(P＞0.05)； on the 14th day after operation，the above indexes of blood flow in the two groups were decreased when compared with those on the first day after operation(P＜0.05)， and the indexes in the observation group were lower than those in the control group(P＜0.05). During treatment， no medicine- related adverse reactions occurred in both groups. Conclusion： Shuxuetong injection combined with Binghuang powder based on routine western medicine treatment has a significant effect in preventing DVT after major orthopedic surgery，which can reduce the incidence of DVT，improve blood circulation and alleviate inflammatory responses，with a high safety.