加味通络汤联合西药治疗急性脑出血临床研究
DOI:
作者:
作者单位:

作者简介:

通讯作者:

中图分类号:

R743.34

基金项目:


Clinical Study on Modified Tongluo Tang Combined with Western Medicine for Acute Cerebral Hemorrhage
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    目的:观察加味通络汤联合西药治疗急性脑出血的临床疗效。方法:选取90 例急性脑出血患者,按随机数字表法分为对照组和观察组,每组45 例。对照组给予西药治疗,观察组在对照组基础上加服加味通络汤治疗,2 组均治疗2 周。观察2 组血液流变学、血管内皮细胞功能、神经功能等指标的改善情况。结果:治疗后,2 组全血低切黏度、全血中切黏度、全血高切黏度、红细胞聚集指数、红细胞比容、血小板聚集率(PAG)、血小板计数(BPC)、纤维蛋白原(FIB) 水平均较治疗前降低(P<0.05),观察组全血低切黏度、全血中切黏度、全血高切黏度、红细胞聚集指数、红细胞比容、PAG、BPC、FIB 水平均低于对照组(P<0.05)。治疗后,2 组内皮素-1(ET-1)、神经元特异性烯醇化酶(NSE)、血清铁蛋白(SF)、转铁蛋白(TF)水平及美国国立卫生研究院卒中量表(NIHSS) 评分均较治疗前降低(P<0.05),观察组ET-1、NSE、SF、TF 水平及NIHSS 评分均低于对照组(P<0.05);2 组血管内皮生长因子(VEGF)、一氧化氮(NO) 水平均较治疗前升高(P<0.05),观察组VEGF、NO 水平均高于对照组(P<0.05)。结论:加味通络汤联合西药治疗急性脑出血,可改善患者的血液流变学、血管内皮细胞功能及神经功能,提升其预后水平。

    Abstract:

    Abstract: Objective: To observe the clinical effect of the therapy of modified Tongluo tang combined with western medicine on acute cerebral hemorrhage. Methods:A total of 90 patients with acute cerebral hemorrhage were divided into the control group and the observation group according to the random number table method,with 45 cases in each group. The control group was treated with western medicine,and the observation group was additionally treated with modified Tongluo tang based on the treatment of the control group. Both groups were treated for two weeks. The improvement of the indexes of hemorheology, vascular endothelial cell function and neurological function in the two groups were observed. Results: After treatment,the levels of low-shear,middle-shear and high-shear whole blood viscosity,red cell aggregation index, hematocrit, platelet aggregation rate(PAG), baseline platelet count(BPC) and fibrinogen(FIB) in the two groups were decreased when compared with those before treatment(P<0.05),and the above levels in the observation group were lower than those in the control group(P<0.05). After treatment,the levels of endothelin-1(ET-1),neuron-specific enolase(NSE), serum ferritin(SF) and transferrin(TF) and the scores of National Institutes of Health Stroke Scale(NIHSS) in the two groups were decreased when compared with those before treatment(P<0.05),and the above levels and scores in the observation group were lower than those in the control group(P<0.05);the levels of vascular endothelial growth factor(VEGF) and nitric oxide(NO) in the two groups were increased when compared with those before treatment(P<0.05),and the above levels in the observation group were higher than those in the control group(P<0.05). Conclusion: The therapy of modified Tongluo tang combined with western medicine for acute cerebral hemorrhage can improve the hemorheology, vascular endothelial cell function,neurological function and the level of prognosis of patients.

    参考文献
    相似文献
    引证文献
引用本文

王彦平,张保朝,温昌明,闻公灵,白方会,路海娟.加味通络汤联合西药治疗急性脑出血临床研究[J].新中医,2021,53(24):73-76

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期: 2021-12-27
  • 出版日期: