醒脑静注射液联合西药治疗急性缺血性脑卒中临床
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R743.3


Clinical Study on Xingnaojing Injection Combined with Western Medicine for Acute Ischemic Stroke
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    摘要:

    目的:观察醒脑静注射液联合西药治疗急性缺血性脑卒中(AIS) 的临床疗效。方法:选取100 例AIS 患者,按不同治疗方法分为研究组和对照组各50 例。对照组给予西药治疗,研究组在对照组基础上给予醒脑静注射液治疗,2 组均治疗2 周。比较2 组临床疗效、不良反应发生率;比较2 组治疗前后神经功能、认知功能及血清炎性因子水平。结果:研究组总有效率为88.00%,优于对照组的72.00% (P<0.05)。治疗后,2 组美国国立卫生研究院卒中量表(NIHSS) 评分及血清白细胞介素-6 (IL-6)、肿瘤坏死因子-α (TNF-α)、超敏C-反应蛋白(hs-CRP) 水平均较治疗前降低,蒙特利尔认知评估量表(MoCA) 评分均较治疗前升高(P<0.05);研究组NIHSS 评分及血清IL-6、TNF-α、hs-CRP 水平均低于对照组(P<0.05),MoCA 评分高于对照组(P<0.05)。研究组不良反应发生率为6.00%,对照组不良反应发生率为8.00%,2 组比较,差异无统计学意义(P>0.05)。结论:醒脑静注射液联合西药治疗AIS 疗效确切,可有效改善患者的神经功能、认知功能,减轻炎性反应,安全性好。

    Abstract:

    Abstract: Objective: To observe the clinical effect of Xingnaojing injection combined with western medicine for acute ischemic stroke(AIS). Methods:A total of 100 cases of AIS patients were selected and divided into the study group and the control group according to their different treatment methods, with 50 cases in each group respectively. The control group was treated with western medicine, and the study group was additionally treated with Xingnaojing injection based on the treatment of the control group. Both groups were treated for two weeks. The neurological function, cognitive function and levels of inflammatory factors before and after treatment as well as clinical effects and incidences of adverse reactions in the two groups were compared. Results:The total effective rate was 88.00% in the study group, better than that of 72.00% in the control group(P<0.05). After treatment, the scores of National Institute of Health Stroke Scale(NIHSS) and the levels of interleukin- 6(IL-6), tumor necrosis factor- α(TNF-α) and high-sensitivity c-reactive protein(hs-CRP) in serum in the two groups were decreased when compared with those before treatment, and the scores of Montreal Cognitive Assessment (MoCA) were increased(P<0.05);the NIHSS score and the levels of IL-6, TNF-α and hs-CRP in serum in the study group were lower than those in the control group(P<0.05), and MoCA score was higher(P<0.05). The incidence of adverse reactions was 6.00% in the study group and 8.00% in the control group, there being no significance in the difference(P> 0.05). Conclusion: Xingnaojing injection combined with western medicine for AIS has a definite curative effect, and can effectively improve neurological function and cognitive function and relieve inflammatory responses with good safety.

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叶闻闻,郑开慧,吴建华,章雪娜.醒脑静注射液联合西药治疗急性缺血性脑卒中临床[J].新中医,2021,53(24):69-72

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  • 在线发布日期: 2021-12-27
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