益气健脾汤联合西药雾化吸入治疗肺脾气虚型慢性阻塞性肺疾病稳定期临床研究
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Clinical Study of Yiqi Jianpi Tang Combined with Western Medicine Aerosol Inhalation for Chronic Obstructive Pulmonary Disease of Dual Deficiency of Lung-Spleen Type in Stable Stage
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    摘要:

    目的:观察益气健脾汤联合西药雾化吸入治疗肺脾气虚型慢性阻塞性肺疾病(COPD) 稳定期的临床疗效。方法:选取COPD 患者56 例,随机分为观察组和对照组各28 例。对照组给予沙美特罗替卡松吸入粉雾剂治疗,观察组给予沙美特罗替卡松吸入粉雾剂联合益气健脾汤治疗。2 组均治疗3 个月。观察比较2 组临床疗效、中医证候积分、圣乔治呼吸问卷(SGRQ)评分、6 min 步行距离(6MWT)、血清C-反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α) 水平以及用力肺活量(FVC)、第1 秒用力呼气容积(FEV1)、第1 秒用力呼气容积与用力肺活量比值(FEV1/FVC) 差异。结果:观察组临床总有效率为96.43%,对照组为78.57%,2 组比较,差异有统计学意义(P<0.05)。治疗前,2 组中医证候积分比较,差异无统计学意义(P>0.05);治疗后,2 组中医证候积分均较治疗前降低(P<0.05),且观察组中医证候积分低于对照组(P<0.05)。治疗前,2 组FVC、FEV1、FEV1/FVC 比较,差异无统计学意义(P>0.05);治疗后,2 组FVC、FEV1、FEV1/FVC 均较治疗前升高(P<0.05),且观察组各项指标均高于对照组(P<0.05)。治疗前,2 组SGRQ 中的症状、活动、对日常活动的影响评分及总分比较,差异均无统计学意义(P>0.05);治疗后,2 组SGRQ 各项评分均较治疗前降低(P<0.05),且观察组各项评分均低于对照组(P<0.05)。治疗前,2 组6MWT、CRP、TNF-α水平比较,差异无统计学意义(P>0.05);治疗后,2 组6MWT 较治疗前增加,CRP、TNF-α水平较治疗前降低(P<0.05),且观察组各项指标改善较对照组更显著(P<0.05)。结论:益气健脾汤联合西药雾化吸入治疗肺脾气虚型COPD 稳定期能够减轻患者呼吸系统症状,提高临床疗效,降低气道炎症反应,改善肺部通气功能。

    Abstract:

    Abstract: Objective: To observe the clinical effect of the therapy of Yiqi Jianpi tang combined with western medicine aerosol inhalation on chronic obstructive pulmonary disease(COPD) of dual deficiency of lung- spleen type in stable stage. Methods: A total of 56 cases of patients with COPD were randomly divided into the observation group and the control group, with 28 cases in each group. The control group was treated with aerosol inhalation of salmeterol and fluticasone propionate, and the observation group was treated with the therapy of aerosol inhalation of salmeterol and fluticasone propionate combined with Yiqi Jianpi tang. Both groups were treated for three months. The clinical effects,Chinese medicine syndrome scores, scores of Saint George Respiratory Questionnaire(SGRQ) , distance of Six- Minute Walk Test (6MWT) , the levels of serum C-reactive protein(CRP) and tumor necrosis factor-α(TNF-α) and the differences of forced vital capacity(FVC),forced expiratory volume in one second(FEV1) and the ratio of forced expiratory volume in one second to forced vital capacity(FEV1/FVC) in the two groups were observed and compared. Results:The total clinical effective rate was 96.43% in the observation group, and 78.57% in the control group, the difference being significant(P<0.05). Before treatment,there was no significant difference being found in the comparison of Chinese medicine syndrome scores between the two groups(P>0.05);after treatment,the above scores in the two groups were decreased when compared with those before treatment(P<0.05),and the above score in the observation group was lower than that in the control group(P<0.05). Before treatment,there was no significant difference being found in the comparison of the levels of FVC,FEV1 and FEV1/FVC between the two groups(P>0.05);after treatment,the above levels in the two groups were increased when compared with those before treatment(P<0.05),and the above levels in the observation group were higher than those in the control group (P<0.05). Before treatment, there was no significant difference being found in the comparison of scores of SGRQ in symptoms,activity,and inpact on daily activities and total scores between the two groups(P>0.05);after treatment,the above scores of SGRQ in the two groups were decreased when compared with those before treatment(P<0.05), and the above scores in the observation group were lower than those in the control group(P<0.05). Before treatment,there was no significant difference in the comparison of distance of 6MWT and levels of CRP and TNF- α between the two groups(P> 0.05);after treatment,the distance of 6MWT in the two groups was increased when compared with that before treatment, and the levels of CRP and TNF-α were decreased(P<0.05),and the improvement of each index in the observation group was more significant than that in the control group(P<0.05). Conclusion:The therapy of Yiqi Jianpi tang combined with western medicine aerosol inhalation for patients with COPD of dual deficiency of lung- spleen type in stable stage can alleviate the respiratory symptoms, improve the clinical effect, reduce the inflammatory responses in airway, and improve pulmonary ventilation function.

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李丹,丁纪元,邵婷婷.益气健脾汤联合西药雾化吸入治疗肺脾气虚型慢性阻塞性肺疾病稳定期临床研究[J].新中医,2021,53(24):31-35

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  • 在线发布日期: 2021-12-27
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