Abstract： Objective： To summarize and analyze the modern clinical compatibility and medication rules of yangreinforcing method for acute ischemic stroke through literature research. Methods： The Chinese herbal prescriptions in all clinical research literatures on yang-reinforcing method for acute ischemic stroke before February 2021 were extracted；the database of prescriptions was created by Excel 2016； statistical analysis and cluster analysis on the frequency of Chinese medicine application were performed by SPSS26 statistical software；the association analysis on medicines was performed by IBM SPSS Modeler 18.0. Results：A total of 261 qualified literatures were included in this study，with 212 medicines and 13 346 cases of patients. Among the prescriptions， medicines for invigorating blood and dissolving stasis， supplementing deficiency，calming the liver and extinguishing wind，and clearing heat were most often compatible with yang- reinforcing medicines. Common couplet medicines compatible with yang- reinforcing medicines were Ramulus Cinnamomi - Rhizoma Chuanxiong ， Ramulus Cinnamomi - Radix Angelicae Sinensis ， Ramulus Cinnamomi-Pheretima ， Ramulus Cinnamoni- Radix Paeoniae Rubra and Ramulus Cinnamomi- Semen Persicae. The commonly used prescription for acute ischemic stroke was Buyang Huanwu tang combined with Ramulus Cinnamomi and Radix et Rhizoma Salviae Miltiorrhizae，as well as modified Erchen tang combined with Xiaoxuming tang. Conclusion： The combination of yang- reinforcing medicines with medicines for invigorating blood and dissolving stasis，supplementing deficiency，calming the liver and extinguishing wind， and clearing heat can enhance the clinical effect of preventing and treating acute ischemic stroke.