Abstract： Objective： To observe the preventive effect of Zishen Qinggan Huayu prescription combined with aspirin enteric-coated tablets for preeclampsia(PE) and its effect on pregnancy outcome. Methods：A total of 120 cases of high-risk pregnant women with PE were divided into the control group and the observation group according to the random number table method，with 60 cases in each group. The control group was given oral administration of aspirin enteric-coated tablets，and the obsevation group was additionally treated with Zishen Qinggan Huayu prescription based on the treatment of the control group. Before and after treatment， the changes in Chinese medicine symptom scores， prothrombin time(PT)， activated partial thromboplastin time(APTT)， thrombin time(TT)， and uterine artery hemodynamics including resistance index(RI) and pulsatility index(PI) in the two groups were compared. The incidence and mode of delivery of PE，complications and neonatal outcome in the two groups were observed. Results：After treatment，the main symptoms，secondary symptoms and the total scores of Chinese medicine symptom scores in the two groups were decreased when compared with those before treatment， and the above scores in the observation group were lower than those in the control group， differences being significant(P＜0.05). The total incidence of PE was 8.33% in the observation group，and 20.00% in the control group，the difference being significant(P＜0.05). After treatment， the values of PT， APTT and TT in the two groups were increased when compared with those before treatment，and the above three values in the observation group was higher than that in the control group， differences being significant(P＜0.05). After treatment， the values of RI and PI in the two groups were decreased when compared with those before treatment(P＜0.05)，and the two values in the observation group were lower than those in the control group(P＜0.05). There was no significant difference being found in the comparison of mode of delivery in pregnant women between the two groups(P＞0.05)；the incidence of placental abruption in the observation group was lower than that in the control group(P＜0.05)，and the incidence of oligohydramnios was higher(P＜0.05). The induction rate of perinatal children and the incidence of asphyxia in newborns in the observation group were lower than those in the control group，differences being significant(P＜0.05). During treatment，there was no obvious adverse reactions in pregnant women in the two groups. Conclusion：The application of Zishen Qinggan Huayu prescription combined with aspirin entericcoated tablets for PE high-risk pregnant women can effectively relieve clinical symptoms，improve coagulation function and maternal-infant outcomes，and decrease the risk of PE，with higher safety.