复方血栓通片联合前列地尔注射液治疗糖尿病视网膜病变临床研究
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R587.2

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Clinical Study of Compound Xueshuantong Tablets Combined with Alprostadil Injection for Diabetic Retinopathy
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    摘要:

    目的:观察复方血栓通片联合前列地尔注射液治疗糖尿病视网膜病变(DR) 的临床疗效。方法:选取110 例DR 患者,按随机数字表法分为观察组及对照组各55 例,2 组均给予糖尿病基础治疗,在此基础上对照组给予静脉滴注前列地尔注射液治疗,观察组在对照组基础上给予口服复方血栓通片,以30 d 为1 个疗程,2 组均治疗3 个疗程。观察2 组临床疗效,比较2 组治疗前后眼底病变情况、视网膜中央动脉血流动力学指标[收缩期峰值流速(PSV)、舒张末期流速(EDV)、血流阻力指数(RI) 及搏动指数(PI)]、视力及视野变化情况,观察3 个疗程后2 组肝肾功能情况。结果:观察组临床疗效总有效率为92.73%,对照组为78.18%,2 组比较,差异有统计学意义(P<0.05)。治疗后,2 组眼底出血点、微血脉瘤、棉絮状软性渗出、硬性渗出指标值均较治疗前下降(P<0.05),观察组眼底病变上述4 项指标值均低于对照组(P<0.05)。治疗后,2 组视网膜中央动脉血流动力学PSV、EDV 指标值较治疗前上升,RI、PI 指标值较治疗前下降,观察组PSV、EDV、PI 指标值高于对照组,RI 指标值低于对照组,差异均有统计学意义(P<0.05)。治疗后,2 组视力均较治疗前提升,视野均较治疗前下降,观察组视力高于对照组,视野低于对照组,差异均有统计学意义(P<0.05)。治疗3 个疗程后,2 组经肝肾功能检查,肝肾功能均无明显异常变化。结论:复方血栓通片联合前列地尔注射液治疗DR 疗效显著,可有效改善患者眼底病变,修复视网膜,提高视力、视野,用药安全性较高。

    Abstract:

    Abstract: Objective: To observe the clinical effect of compound Xueshuantong tablets combined with alprostadil injection for diabetic retinopathy(DR). Methods:A total of 110 cases of patients with diabetic retinopathy were selected and divided into the observation group and the control group according to the random number table method, with 55 cases in each group. Both groups were given basic treatment of diabetes. The control group was additionally given intravenous infusion of alprostadil injection, and the observation group was additionally given oral administration of compound Xueshuantong tablets based on the treatment of the control group. The two groups were treated for three courses,30 days being a course. The clinical effects in the two groups were observed. Before and after treatment,the levels of fundus lesions,hemodynamic indexes of central retinal artery [peak systolic velocity(PSV),end-diastolic velocity(EDV),blood flow resistance index(RI) and pulsatility index(PI)] as well as changes of visual acuity and visual field in the two groups were compared. After three courses of treatment,the liver and kidney functions in the two groups were observed. Results:The total clinical effective rate was 92.73% in the observation group, and was 78.18% in the control group, the difference being significant(P<0.05). After treatment,the indexes of spots of retinal hemorrhage,micro hemangioma,cotton- wool spots and hard exudation in the two groups were decreased when compared with those before treatment(P<0.05), and the above four indexes of fundus lesions in the observation group were lower than those in the control group(P<0.05). After treatment, the PSV and EDV indexes of hemodynamics of central retinal artery in the two groups were increased when compared with those before treatment,and the RI and PI indexes were decreased;the PSV,EDV,PI indexes in the observation group were higher than those in the control group, the RI index value in the observation group was lower, differences being significant(P<0.05). After treatment,the visual acuity in the two groups was improved when compared with that before treatment,and the visual field was narrowed;the visual acuity in the observation group was higher than that in the control group,and the visual field was narrower,differences being significant(P<0.05). After three courses of treatment,the liver and kidney functions in the two groups showed no anomalous changes. Conclusion: Compound Xueshuantong tablets combined with alprostadil injection for DR has a significant curative effect,which can effectively improve the fundus lesions of patients,repair the local microcirculation of retina,and improve their visual acuity and visual field,with high safety.

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林霞.复方血栓通片联合前列地尔注射液治疗糖尿病视网膜病变临床研究[J].新中医,2021,53(23):121-124

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  • 在线发布日期: 2021-12-10
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