Abstract： Objective： To observe the clinical effect of Xuebijing injection in adjuvant therapy of ventilator- associated pneumonia(VAP) due to multidrug- resistant pseudomonas aeruginosa(MDR- PA). Methods：A total of 48 cases of patients with VAP due to MDR-PA were selected and divided into the control group and the observation group according to random number table method，with 24 cases in each group. The control group was treated with routine western medicine，and the observation group was additionally treated with Xuebijing injection based on the treatment of the control group. Scores of the Acute Physiology and Chronic Health Evaluation Ⅱ (APACHE Ⅱ)， Clinical Pulmonary Infection Score(CPIS)， duration of mechanical ventilation，hospitalization time at Intensive care unit(ICU)，peak inspiratory pressure(PIP) and airway resistance (RAW) before and after treatment in the two groups were compared. Results：Before treatment，there was no significant difference being found in the comparison of scores of APACHE Ⅱ and CPIS between the two groups(P＞0.05). After treatment，scores of APACHE Ⅱ and CPIS in the two groups were decreased when compared with those before treatment， and the two scores in the observation group were lower than those in the control group， differences being significant(P＜ 0.05). Duration of mechanical ventilation and hospitalization time at ICU in the observation group were shorter than those in the control group(P＜0.05). Negative conversion rate of MDR-PA was 54.2% in the observation group，higher than that of 25.0% in the control group，the difference being significant(P＜0.05). Before treatment，there was no significant difference being found in the comparison of PIP and RAW between the two groups(P＞0.05). After treatment，PIP and RAW in the two groups were lower than those before treatment，and the two indexes in the observation group were lower than those in the control group， the difference being significant(P＜0.05). Conclusion： In the adjuvant therapy of VAP due to MDR- PA， Xuebijing injection can improve pulmonary infection and respiratory function， shorten duration of mechanical ventilation and ICU hospitalization time，and enhance bacterial clearance rate.