Abstract： Objective： To observe the clinical effect and safety of modified Zuojin pills combined with routine western medicine for reflux esophagitis(RE) of liver and stomach depression-heat type. Methods：A total of 80 cases of RE patients of liver and stomach depression-heat type were selected as the study subjects and divided into the observation group and the control group according to the random number table method， 40 cases in each group. The control group was treated with rabeprazole sodium enteric-coated capsule and mosapride citrate tablets，and the observation group was additionally treated with modified Zuojin pills based on the treatment of the control group. After treatment for eight weeks，the clinical effects， the changes in levels of gastrointestinal hormones in serum and the safety in the two groups were compared. Results：The total effective rate was 95.00% in the observation group， higher than that of 70.00% in the control group(P＜0.05). After treatment，the endoscopy scores and levels of vasoactive intestinal peptide(VIP) and somatostatin(SS) in serum in the two groups were decreased when compared with those before treatment(P＜0.05)， and the levels of gastrin(GAS) and motilin (MTL) in serum were increased(P＜0.05)；the endoscopy score and levels of VIP and SS in serum in the observation group were lower than those in the control group(P＜0.05)，and levels of GAS and MTL in serum were higher(P＜0.05). There was no significant difference being found in the comparison of medication safety between the two groups(P＞0.05). Conclusion： Modified Zuojin pills combined with routine western medicine is effective and safe in treating RE of liver and stomach depression-heat type.