Abstract： Objective： To observe the clinical effect of Chaihu Siwu tang combined with antibiotics for chronic pelvic inflammatory disease and its effect on inflammatory factors. Methods：The clinical data of 104 cases of patients with chronic pelvic inflammatory disease were retrospectively analyzed. According to the treatment methods in the data， the patients were divided into the treatment group and the control group， 52 cases in each group. The control group was treated with antibiotics， and the treatment group was additionally treated with Chaihu Siwu tang based on the treatment of the control group. The levels of tumor necrosis factor- α(TNF- α)， interleukin- 2(IL- 2)， interleukin- 6(IL- 6)， superoxide dismutase (SOD)，malondialdehyde(MDA) and glutathione peroxidase(GSH-Px) before and after treatment as well as the clinical effects and the incidences of adverse reactions in the two groups were compared. Results：The total effective rate was 96.15% in the treatment group， higher than that of 82.69% in the control group(P＜0.05). After treatment， the levels of TNF- α and MDA in the two groups were decreased when compared with those before treatment(P＜0.05)，and the levels of IL-2，IL-6， SOD and GSH-Px were increased(P＜0.05)；the levels of TNF-α and MDA in the treatment group were lower than those in the control group(P＜0.05)，and the levels of IL-2，IL-6，SOD and GSH-Px were higher(P＜0.05). The incidence of adverse reactions was 5.77% in the treatment group， lower than that of 21.15% in the control group(P＜0.05). Conclusion： The therapy of Chaihu Siwu tang combined with antibiotics for chronic pelvic inflammatory disease can significantly improve the curative effect，effectively enhance antioxidant capacity，reduce inflammatory responses and the adverse reactions during treatment.