Abstract：Objective：To observe the wake-promoting effect of Angong Niuhuang pills assisting routine basic therapy for patients with coma due to acute severe traumatic brain injury and its effect on the levels of B-type natriuretic peptide(BNP) and high-sensitivity C-reactive protein(hs-CRP) in serum. Methods：A total of 50 cases of patients with coma due to acute severe traumatic brain injury were divided into the control group and the observation group according to the random number table method，with 25 cases in each group. The control group was given routine basic treatment，and the observation group was additionally treated with Angong Niuhuang pills based on the treatment of the control group. The changes in the scores of National Institutes of Health Stroke Scale(NIHSS) and Glasgow Coma Scale(GCS) as well as the levels of BNP and hs-CRP in serum before and after treatment in the two groups were compared； clinical effects， wake- promoting effects and the incidences of complications in the two groups were evaluated. Results： The total effective rate was 88.00% in the observation group，higher than that of 64.00% in the control group，the difference being significant(P＜0.05). The awaking rate was 84.00% in the observation group， higher than that of 56.00% in the control group， and the recovery time in the observation group was earlier than that in the control group(P＜0.05). After treatment，NIHSS scores in the two groups were lower than those before treatment，and GCS scores were higher(P＜0.05)；NIHSS score in the observation group was lower than that in the control group，and GCS score was higher(P＜0.05). After treatment，serum BNP levels in the two groups were higher than those before treatment，and hs-CRP levels were lower(P＜0.05)；BNP level in the observation group was higher than that in the control group，and hs-CRP level was lower(P＜0.05). The incidence of complications was 12.00% in the observation group， lower than that of 40.00% in the control group， the difference being significant(P＜0.05). Conclusion：The therapy of Angong Niuhuang pills assisting routine basic therapy for patients with coma due to acute severe traumatic brain injury has a significant curative effect，and can shorten the time for patients to wake up，improve the degree of neurological impairment， coma and the prognosis of patients， relieve systemic inflammatory responses and reduce complications.