Abstract： Objective： To observe the clinical effect of Shenling Baizhu powder combined with Erchen tang for chronic spleen and stomach diseases of spleen deficiency type. Methods：A total of 102 cases of patients with chronic spleen and stomach diseases of spleen deficiency type were selected and divided into the study group and the control group according to the random number table method， with 51 cases in each group. Both groups were treated with routine symptomatic treatment； the control group was additionally treated with Shenling Baizhu powder， and the study group was additionally treated with Shenling Baizhu powder combined with Erchen tang. Before and after treatment， the changes in Chinese medicine symptom scores，gastrin，peroxidation indexes and hemorheology in the two groups were compared. The clinical effects were evaluated. Results：The total effective rate was 90.20% in the study group，higher than that of 74.51% in the control group， the difference being significant(P＜0.05). After treatment， the symptom scores including poor appetite， abdominal distension after eating， fatigue and lack of strength， abnormal defecation， continual mild abdominal pain and rugitus and gastric stuffiness in the two groups were significantly decreased when compared with those before treatment(P＜ 0.05)， and the above symptom scores in the study group were lower than those in the control group(P＜0.05). After treatment， the levels of gastrin and superoxide dismutase(SOD) in the two groups were significantly increased when compared with those before treatment，and malondialdehyde(MDA) levels were significantly decreased(P＜0.05)；the levels of gastrin and SOD in the study group were higher than those in the control group， and MDA was lower(P＜0.05). After treatment，low-shear whole blood viscosity，high-shear whole blood viscosity and plasma viscosity in the two groups were significantly decreased when compared with those before treatment， and deformation indexes(DI) of red blood cells were significantly increased(P＜0.05)； the levels of low- shear whole blood viscosity， high- shear whole blood viscosity and plasma viscosity in the study group were lower than those in the control group， DI was higher(P＜0.05). Conclusion： Shenling Baizhu powder combined with Erchen tang can effectively regulate gastrin secretion and peroxide levels of patients， improve hemorheology and promote the disease outcome of patients with chronic spleen and stomach diseases of the spleen deficiency type.