竹叶石膏汤联合西格列汀治疗老年2型糖尿病临床研究
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Clinical Study on Zhuye Shigao Tang Combined with Sitagliptin for Elderly Patients with Type 2 Diabetes Mellitus
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    摘要:

    目的:观察竹叶石膏汤联合西格列汀对老年2 型糖尿病患者糖脂代谢、氧化应激的影响。方法:将120 例老年2 型糖尿病患者按随机数字表法分为对照组和观察组各60 例。对照组给予西格列汀治疗,观察组在对照组基础上加用竹叶石膏汤治疗。观察2 组治疗前后糖脂代谢指标[空腹血糖(FBG)、糖化血红蛋白(HbAlc)、血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)] 和氧化应激指标[超氧化物歧化酶(SOD)、丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-Px)、活性氧类物质(ROS)] 水平,并评价2 组临床疗效和不良反应发生情况。结果:观察组总有效率为95.00%,高于对照组81.67%,差异有统计学意义(χ2=5.175,P=0.023)。治疗后,2 组FBG、HbA1c、TC、LDL-C 水平较治疗前降低,且观察组糖脂代谢指标水平低于对照组(P<0.05)。治疗后,2 组SOD、GSH-Px 水平较治疗前升高,MDA、ROS 水平降低,且观察组氧化应激水平优于对照组(P<0.05)。2 组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:竹叶石膏汤联合西格列汀治疗老年2 型糖尿病疗效显著,能有效改善患者糖脂代谢功能,减轻氧化应激损伤,不良反应少。

    Abstract:

    Abstract:Objective:To observe the effect of the therapy of Zhuye Shigao tang combined with sitagliptin on glucose and lipid metabolism and oxidative stress in elderly patients with type 2 diabetes mellitus. Methods:A total of 120 elderly patients with type 2 diabetes mellitus were divided into the control group and the observation group according to the random number table method,with 60 cases in each group. The control group was treated with sitagliptin,and the observation group was additionally treated with Zhuye Shigao tang based on the treatment of the control group. The levels of indexes of glucose and lipid metabolism including fasting blood glucose(FBG), glycosylated hemoglobin(HbA1c), total cholesterol(TC), and lowdensity lipoprotein cholesterol(LDL-C) and indexes of oxidative stress including superoxide dismutase(SOD),malondialdehyde (MDA),glutathione peroxidase(GSH-Px),reactive oxygen species(ROS) were observed before and after treatment,and the clinical effects and adverse reactions were evaluated. Results:The total effective rate was 95.00% in the observation group, higher than that of 81.67% in the control group,the difference being significant(χ 2=5.175,P=0.023). After treatment,the levels of FBG,HbA1c,TC and LDL-C in the two groups were decreased when compared with those before treatment,and the levels of indexes of glucose and lipid metabolism in the observation group were lower than those in the control group(P< 0.05). After treatment,the levels of SOD and GSH-Px in the two groups were increased when compared with those before treatment,and the levels of MDA and ROS were decreased,and the level of oxidative stress in the observation group was better than that in the control group(P<0.05). There was no significant difference being found in the comparison of incidence of adverse reactions between the two groups(P>0.05). Conclusion: The therapy of Zhuye Shigao tang combined with sitagliptin for elderly patients with type 2 diabetes mellitus has a significant curative effect,which can effectively improve the glucose and lipid metabolism function and reduce the oxidative stress injury,with few adverse reactions.

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章联欢,王冰清,孙莉,冯梦雪.竹叶石膏汤联合西格列汀治疗老年2型糖尿病临床研究[J].新中医,2021,53(23):35-38

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  • 在线发布日期: 2021-12-10
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