Abstract：This paper introduces the experience of Professor WU Liangcun skillfully using Shashen Maidong tang in the treatment of various symptoms after endocrine therapy of breast cancer. Professor WU Liangcun holds that yin deficiency is the main syndrome clinically after endocrine therapy of breast cancer. The cause is generally related to the damage of endocrine medicine to the kidney- heavenly tenth- thoroughfare and conception vessels- uterus ；the kidney deficiency will lead to the early failure of the heavenly tenth，and the disharmony of thoroughfare and conception vessels will result in the dysfunction of the uterus ；what's more，there will be similar climacteric syndrome which is associated with the liver，the kidney， the spleen and the lung. Thus， the main treatment is to nourish yin. It is suggested that the syndromes of the disease are mainly yin deficiency and the lung heat，qi-yin deficiency，and the liver-kidney yin deficiency ；therefore，the syndrome of upper heat， middle encumbrance， and lower deficiency should be solved by a subtle application of Shashen Maidong tang which is modified according to different syndromes. A medical case is attached as evidence.