Clinical Study on Modified Tianma Gouteng Yin Combined with Western Medicine for Gestational Hypertension
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摘要:
目的:观察天麻钩藤饮加减联合西药治疗妊娠期高血压的临床疗效。方法:将纳入研究的96 例肝风内动型妊娠期高血压患者随机分为2 组,2 组均予硫酸镁注射液、盐酸拉贝洛尔片治疗,观察组加用天麻钩藤饮加减,2 组均治疗7 d。于治疗前和治疗7 d 后监测24 h 动态血压、评定中医证候积分、检测血清指标[超氧化物歧化酶(SOD)、谷胱甘肽过氧化酶(GSH-PX)、总抗氧化能力(T-AOC)、丙二醛(MAD)]。比较2 组的临床疗效和不良妊娠结局的发生率。结果:治疗后,观察组临床疗效总有效率高于对照组(P<0.05)。2 组24 h 收缩压及舒张压均较治疗前下降(P<0.05),观察组24 h 收缩压及舒张压均低于对照组(P<0.05)。2 组中医证候积分均较治疗前下降(P<0.05),观察组中医证候积分低于对照组(P<0.05)。2 组SOD、GSH-PX、T-AOC 均较治疗前升高,MAD 均较治疗前降低,差异均有统计学意义(P<0.05);观察组SOD、GSH-PX、T-AOC均高于对照组,MAD 低于对照组,差异均有统计学意义(P<0.05)。观察组不良妊娠结局发生率10.42%,低于对照组的27.08%,差异有统计学意义(P<0.05)。结论:在西药基础上加用天麻钩藤饮加减治疗肝风内动型妊娠期高血压患者,可促进血压恢复正常,改善中医证候,其作用机制可能与改善机体的氧化机制有关。
Abstract:
Abstract:Objective:To observe the clinical effect of modified Tianma Gouteng yin combined with western medicine for gestational hypertension. Methods: A total of 96 cases of patients with gestational hypertension of internal stirring of liver wind type were randomly divided into two groups. Both groups were treated with magnesium sulfate injection and labetalol hydrochloride tablets, and the observation group was additionally treated with modified Tianma Gouteng yin. Both groups were treated for seven days. Before treatment and after seven- day treatment, 24- hour ambulatory blood pressure was monitored; Chinese medicine syndrome scores were evaluated; serum indexes including superoxide dismutase(SOD), glutathione peroxidase(GSH-PX),total antioxidant capacity(T-AOC) and malonaldehyde(MAD) were detected. Clinical effect and incidence of adverse pregnancy outcomes were compared between the two groups. Results:After treatment,the total clinical effective rate in the observation group was higher than that in the control group(P<0.05). The 24-hour systolic blood pressure and diastolic blood pressure in the two groups were decreased when compared with those before treatment(P< 0.05),and 24-hour systolic blood pressure and diastolic blood pressure in the observation group were lower than those in the control group(P<0.05). Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment(P<0.05),and the score in the observation group was lower than that in the control group(P<0.05). SOD, GSH- PX and T- AOC in the two groups were increased when compared with those before treatment, and MAD was decreased, differences being significant(P<0.05). SOD, GSH- PX and T- AOC in the observation group were higher than those in the control group,and MAD was lower,differences being significant(P<0.05). The incidence of adverse pregnancy outcome was 10.42% in the observation group, lower than that of 27.08% in the control group, the difference being significant(P<0.05). Conclusion:Based on western medicine,the additional application of modified Tianma Gouteng yin for gestational hypertension of internal stirring of liver wind type can promote blood pressure to return to normal and improve Chinese medicine syndromes,whose mechanism may be related to the improvement of oxidation mechanism of organism.