Abstract： Objective： To observe the therapeutic effect of the therapy of Kunfukang tablets combined with western medicine on chronic pelvic inflammatory disease and its effect on oxidative stress factors. Methods：According to the random number table method，128 patients with chronic pelvic inflammatory disease were divided into the experiment group and the control group，64 cases in each group. The control group was treated with ceftriaxone sodium and metronidazole，and the experiment group was additionally treated with Kunfukang tablets based on the treatment of the control group. The clinical effect，malondialdehyde(MDA)，advanced oxidized protein product(AOPP)，superoxide dismutase(SOD)，interleukin-2(IL-2)， interleukin-21(IL-21)，tumor necrosis factor-α(TNF-α) and Chinese medicine syndrome scores before and after treatment were compared between the two groups. Results：The total effective rate was 93.75% in the experiment group，significantly higher than that of 81.25% in the control group(P＜0.05). Compared with those before treatment， the levels of MDA， AOPP，IL- 2，IL- 21，TNF- α and Chinese medicine syndrome scores in both groups were decreased after treatment(P＜ 0.05)，and the levels of SOD were increased(P＜0.05)；Compared with those in the control group after treatment，the levels of MDA，AOPP，IL- 2，IL- 21，TNF- α and Chinese medicine syndrome scores in the experiment group were lower(P＜ 0.05)， and the level of SOD was higher(P＜0.05). Conclusion： The therapy of Kunfukang tablets combined with western medicine for chronic pelvic inflammatory disease can significantly improve the clinical effect， effectively reduce oxidative stress and inflammatory stress response，as well as improve the clinical symptoms of patients.