醒脑静注射液辅助治疗急性重型颅脑损伤对改善脑水肿、脑缺氧状态的临床研究
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R651.15

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浙江省基础公益研究计划项目(LGF19H090007)


Clinical Study on Xingnaojing Injection for Acute Severe Brain Injury to Improve Brain Edema and Cerebral Anoxia
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    摘要:

    目的:观察醒脑静注射液辅助治疗急性重型颅脑损伤对改善脑水肿、脑缺氧状态的临床效果。方法:选取96 例急性重型颅脑损伤患者,以简单随机化法分为对照组与观察组各48 例。对照组采取大骨瓣减压术治疗,观察组在对照组基础上给予醒脑静注射液辅助治疗。观察2 组临床疗效及治疗前后脑水肿面积、脑缺氧状态、昏迷程度及炎性因子水平变化情况。结果:观察组临床总有效率91.67%,高于对照组72.92%(P<0.05)。与同组治疗前比较,治疗后2 组脑水肿面积减小(P<0.05),氧减饱和度指数、血清白细胞介素-2 (IL-2)、肿瘤坏死因子-α (TNF-α) 水平均降低(P<0.05),格拉斯哥昏迷量表(GCS) 评分、低血氧饱和度、血清白细胞介素-4 (IL-4) 水平升高(P<0.05);与对照组治疗后比较,观察组治疗后脑水肿面积较小(P<0.05),氧减饱和度指数、血清IL-2、TNF-α 水平均较低(P<0.05),GCS 评分、低血氧饱和度、血清IL-4 水平均较高(P<0.05)。结论:醒脑静注射液辅助治疗急性重型颅脑损伤疗效显著,可缩小患者脑水肿面积,纠正患者脑缺氧状态,改善昏迷程度,并能减轻炎症反应。

    Abstract:

    Abstract:Objective:To observe the clinical effect of Xingnaojing injection for acute severe brain injury on improving brain edema and cerebral hypoxia. Methods:A total of 96 cases of patients with acute severe brain injury were randomly divided into the control group and the observation group, with 48 cases in each group. The control group was treated with large decompressive craniectomy, and the observation group was additionally treated with Xingnaojing injection based on the treatment of the control group. The changes of brain edema areas,states of brain hypoxia,coma degrees and inflammatory factor levels before and after treatment and the clinical effects in the two groups were observed. Results:The total effective rate was 91.67% in the observation group,higher than that of 72.92% in the control group(P<0.05). After treatment,the brain edema areas in the two groups were decreased when compared with those before treatment(P<0.05), oxygen desaturation values,serum interleukin- 2(IL- 2) and tumor necrosis factor- α(TNF- α) levels were decreased(P<0.05),and Glasgow Coma Scale(GCS) scores, low oxygen saturations and serum interleukin- 4(IL- 4) levels were increased(P<0.05). After treatment,the brain edema area in the observation group was smaller than that in the control group(P<0.05),oxygen desaturation value,serum IL-2 and TNF-α level were lower(P<0.05),and GCS score,low oxygen saturation and serum IL-4 level were higher(P<0.05). Conclusion: Xingnaojing injection for acute severe brain injury has a significant curative effect, which can reduce the brain edema area, correct the state of brain hypoxia, improve coma degree, and reduce the inflammatory responses.

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邱峰,秦福创,宋春艳,田斯琦,曾剑平,黄蓉.醒脑静注射液辅助治疗急性重型颅脑损伤对改善脑水肿、脑缺氧状态的临床研究[J].新中医,2021,53(21):88-91

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  • 在线发布日期: 2021-11-12
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