桂枝茯苓胶囊联合头孢呋辛钠治疗慢性盆腔炎临床研究
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R711.33

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Clinical Study on Guizhi Fuling Capsules Combined with Cefuroxime Sodium for Chronic Pelvic Inflammatory Disease
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    摘要:

    目的:观察桂枝茯苓胶囊联合头孢呋辛钠治疗慢性盆腔炎的临床疗效及对炎症反应、氧化指标的影响。方法:将112 例慢性盆腔炎患者按随机数字表法分为观察组和对照组各56 例。对照组给予头孢呋辛钠治疗,观察组在对照组基础上给予桂枝茯苓胶囊治疗。比较2 组治疗前后炎症因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-2(IL-2)、白细胞介素-6(IL-6)]和氧化指标[超氧化物歧化酶(SOD)、丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-Px)] 水平变化,统计2 组临床疗效和不良反应发生情况。结果:观察组总有效率为94.64%,高于对照组80.36%,差异有统计学意义(P<0.05)。治疗前,2 组TNF-α、IL-2、IL-6 水平比较,差异无统计学意义(P>0.05)。治疗后,2 组IL-2、IL-6 水平均高于治疗前,TNF-α 水平低于治疗前(P<0.05);且观察组IL-2、IL-6 水平高于对照组,TNF-α 水平低于对照组(P<0.05)。治疗前,2 组SOD、MDA、GSH-Px水平比较,差异无统计学意义(P>0.05)。治疗后,2 组SOD、GSH-Px 水平较治疗前升高,且观察组SOD、GSH-Px 水平均高于对照组;2 组MDA 水平较治疗前降低,且观察组MDA 水平低于对照组;差异均有统计学意义(P<0.05)。观察组不良反应发生率为3.57%,对照组为8.93%,2 组比较,差异无统计学意义(χ2=0.242,P=1.371)。结论:桂枝茯苓胶囊联合头孢呋辛钠治疗慢性盆腔炎疗效显著,可有效提高患者抗氧化能力,降低炎症反应,安全性较好。

    Abstract:

    Abstract: Objective: To observe the clinical effect of Guizhi Fuling capsules combined with cefuroxime sodium for chronic pelvic inflammatory disease and its effect on inflammatory responses and antioxidant indexes. Methods: A total of 112 cases of patients with chronic pelvic inflammatory disease were divided into the observation group and the control group according to the random number table method,with 56 cases in each group. The control group was treated with cefuroxime sodium,and the observation group was additionally treated with Guizhi Fuling capsules based on the treatment of the control group. The changes in the levels of inflammatory factors including tumor necrosis factor- α(TNF-α),interleukin-2(IL-2) and IL- 6 as well as oxidation indexes including superoxide dismutase(SOD), malonaldehyde(MDA) and glutathione peroxidase (GSH- Px) before and after treatment in the two groups were compared;the clinical effects and the incidences of adverse reactions in the two groups were counted. Results: The total effective rate was 94.64% in the observation group, higher than that of 80.36% in the control group, the difference being significant(P<0.05). Before treatment, there was no significant difference being found in the comparison of the levels of TNF-α,IL-2 and IL-6 between the two groups(P>0.05). After treatment,the levels of IL-2 and IL-6 in the two groups were higher than those before treatment,and the levels of TNF- α were lower(P<0.05); the levels of IL- 2 and IL- 6 in the observation group were higher than those in the control group,and the level of TNF-α was lower(P<0.05). Before treatment,there was no significant difference being found in the comparison of the levels of SOD,MDA and GSH-Px between the two groups(P>0.05). After treatment,the levels of SOD and GSH- Px in the two groups were increased when compared with those before treatment, and the levels of SOD and GSH-Px in the observation group were higher than those in the control group;MDA levels in the two groups were decreased when compared with those before treatment, and MDA level in the observation group was lower than that in the control group, differences being significant(P<0.05). The incidence of adverse reactions was 3.57% in the observation group and 8.93% in the control group,there being no significant difference between the two groups(χ2=0.242,P=1.371). Conclusion: The therapy of Guizhi Fuling capsules combined with cefuroxime sodium has a significant curative effect in treating chronic pelvic inflammatory disease, which can effectively improve the antioxidant capacity of patients, and reduce inflammatory responses with good safety.

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吕红芳,徐晓聪,方笑爱,孙成艳,胡笑玲.桂枝茯苓胶囊联合头孢呋辛钠治疗慢性盆腔炎临床研究[J].新中医,2021,53(21):51-54

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  • 在线发布日期: 2021-11-12
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