Abstract： Objective： To observe the clinical effect of point application and acupuncture based on routine therapy for insomnia after ischemic stroke of internal obstruction of blood stasis type and its effect on contents of dopamine(DA) in plasma. Methods：A total of 88 cases of patients with ischemic stroke complicated with insomnia were included and divided into the control group and the observation group according to the random number table method，44 cases in each group. Both groups were given routine treatment plan and treated with eszopiclone tablets，and the observation group was additionally treated with point application with Zhuyang Tongqi prescription and acupuncture therapy. Both groups were treated for four weeks. The scores of Pittsburg Sleep Quality Index(PSQI)，the results of polysomnography and the contents of plasma DA in one day before treatment and after four-week treatment respectively as well as the clinical effect after four-week treatment in the two groups were compared. Results：After four-week treatment，the total effective rate in the observation group was higher than that in the control group(P＜0.05). The PSQI scores of fall asleep time， sleep efficiency， sleep disorders and daytime dysfunction in the two groups were decreased when compared with those in one day before treatment(P＜0.01)， and the above five scores in the observation group was lower than that in the control group(P＜0.01). The total sleep time in the two groups was increased when compared with that in one day before treatment，and the sleep latency and the number of wakefulness were shortened or decreased when compared with those before treatment(P＜0.01). The total sleep time in the observation group was longer than that in the control group，and the sleep latency and the number of wakefulness were shorter or fewer than those in the control group(P＜0.01). The contents of plasma DA in the two groups were decreased when compared with those before treatment(P＜0.01)，and the content in the observation group was lower than that in the control group(P＜0.01). Conclusion： Based on routine therapy， the additional application of point application combined with acupuncture for patients with insomnia after ischemic stroke of internal obstruction of blood stasis type has significant curative effect in improving insomnia and sleep quality，and the down-regulation of contents of DA may be related to its curative effect.