Abstract： Objective： To observe the clinical effect of acupuncture combined with joint mobilization for cervical spondylosis with radiculopathy. Methods：A total of 106 cases of cervical spondylosis with radiculopathy were selected and randomly divided into the observation group and the control group，53 cases in each group. The control group was treated with joint mobilization，and the observation group was additionally treated with acupuncture based on the treatment of the control group. Both groups were treated for three treatment courses，10 days being a course. After treatment，the curative effect was evaluated. Before and after treatment，pain，range of motion of cervical spine，cervical dysfunction and Clinical Assessment Scale for Cervical Spondylosis(CASCS) score were observed， analyzed and compared in the two groups. Results： The total effective rate was 90.57% in the observation group， and 75.47% in the control group， the difference being significant(P＜0.05). Before treatment，when compared scores of Pain Rating Index(PRI)，Visual Analogue Scale(VAS)， and present pain intensity(PPI) of Short- form McGill Pain Questionnaire(SF- MPQ) between the two groups，there was no significance in the difference(P＞0.05). After treatment，each pain score of SF-MPQ in the two groups was decreased when compared with that before treatment(P＜0.05)，and each score in the observation group was lower than that in the control group(P＜0.05). Before treatment，when compared the range of motion of cervical anteflexion，back extension，left flexion， right flexion，left rotation and right rotation，there was no significant difference being found in the comparison between the two groups(P＞0.05). After treatment，each index of range of motion of cervical spine in the two groups was increased when compared with that before treatment(P＜0.05)，and each index in the observation group was larger than that in the control group(P＜0.05). Before treatment，there was no significant difference being found in the comparison of cervical dysfunction between the two groups(P＞0.05). After treatment， the condition of cervical dysfunction in the two groups was improved when compared with that before treatment(P＜0.05)，and the improvement in the observation group was better than that in the control group(P＜0.05). Before treatment， when compared scores of subjective symptoms， adaptability， and clinical physical signs， as well as the total score of CASCS， there was no significant difference being found in the comparison between the two groups(P＞0.05). After treatment，scores of each dimension and the total score of CASCS in the two groups were increased when compared with those before treatment(P＜0.05)，and the scores in the observation group were higher than those in the control group(P＜0.05). Conclusion： The therapy of acupuncture combined with joint mobilization has a significant curative effect in the treatment of cervical spondylosis with radiculopathy， which is better than simple joint mobilization in relieving pain，and improving cervical range of motion and cervical dysfunction.