Abstract： Objective： To observe the clinical effect of thumbtack needle combined with fluoxetine for post- stroke depression. Methods：A total of 106 cases of patients with post-stroke depression were selected and randomly divided into the control group and the observation group， 53 cases in each group. The control group was treated with fluoxetine hydrochloride capsules，and the observation group was additionally treated with thumbtack needle based on the treatment of the control group. Both groups were treated for eight weeks. Hamilton Depression Scale- 17(HAMD-17) scores and Barthel indexes before and after treatment as well as clinical effects in the two groups were compared. Results：The total effective rate was 92.45% in the observation group， higher than that of 77.36% in the control group(P＜0.05). After treatment， HAMD-17 scores in the two groups were decreased when compared with those before treatment(P＜0.05)，and the HAMD-17 score in the observation group was lower than that in the control group(P＜0.05)； Barthel indexes in the two groups were increased when compared with those before treatment(P＜0.05)，and the Barthel index in the observation group was higher than that in the control group(P＜0.05). Conclusion： The therapy of thumbtack needle combined with fluoxetine for poststroke depression can enhance the clinical effect， reduce the degree of depression and improve the self- care ability of patients.