Abstract： Objective： To observe the clinical effect of Huoxue Zhitong Zhuanggu tang combined with rehabilitation training for patients after operation for distal radius fracture. Methods：A total of 80 cases of patients after operation for distal radius fracture were selected and divided into the control group and the observation group according to the random number table method，40 cases in each group. Both groups were treated with open reduction and internal fixation. After operation， the control group was treated with cefuroxime sodium for injection combined with rehabilitation training，and the observation group was additionally treated with Huoxue Zhitong Zhuanggu tang based on the treatment of the control group. Both groups were intervened for six months. The postoperative fracture healing time and wrist deswelling time were compared between the two groups；the pain degree before and after treatment，the bone mineral density of radius at different periods before and after operation，and wrist function in six months after operation were compared between the two groups；the incidence of adverse reactions were compared between the two groups. Results： The postoperative fracture healing time and wrist deswelling time in the observation group were shorter than those in the control group(P＜0.05). After treatment，the scores of Visual Analogue Scale(VAS) in the two groups were decreased when compared with those before treatment(P＜0.05)， and VAS score in the observation group was lower than that in the control group(P ＜ 0.05). In one ， three and six months after operation respectively，the bone mineral density of radius in the two groups was increased when compared with that before operation(P＜0.05)， and the bone mineral density of radius in the observation group was higher than that in the control group(P＜0.05). In six months after operation，the superior rate of wrist function was 92.5% in the observation group， higher than that of 75.0% in the control group(P＜0.05). The incidence of adverse reactions was 2.5% in the observation group and 7.5% in the control group， there being no significant difference between the two groups(P＞0.05). Conclusion：The therapy of Huoxue Zhitong Zhuanggu tang combined with rehabilitation training for patients after operation for distal radius fracture can relieve pain， enhance bone mineral density， shorten postoperative fracture healing time and wrist deswelling time，and improve wrist function with high safety.