Abstract：Objective：To observe the clinical effect of Yiqi Guben tang combined with tiotropium bromide for patients with chronic obstructive pulmonary disease(COPD) at stable stage， and its effect on the lung function and levels of ischemia modified albumin(IMA) and serum amyloid A(SAA). Methods： A total of 120 cases of COPD patients at stable stage were selected and randomly divided into the observation group and the control group，60 cases in each group. The control group was treated with tiotropium bromide inhalation powder，and the observation group was additionally treated with Yiqi Guben tang based on the treatment of the control group. The clinical effect was observed and compared between the two groups. Before and after treatment，changes in Chinese medicine syndrome scores，forced expiratory volume in one second(FEV1)， of the lung function，forced expiratory volume in one second as a percentage of estimated value(FEV1% pred)，forced expiratory volume in one second to forced vital capacity(FEV1/FVC)，and levels of IMA and SAA in serum were observed and compared between the two groups. Results：The total effective rate was 93.33% in the observation group，and 75.00% in the control group， the difference being significant(P＜0.05). Before treatment， there was no significant difference being found in the comparison of Chinese medicine symptom scores between the two groups(P＞0.05). After treatment， scores of cough， expectoration，chest pain，dyspnea，dark and lusterless complexion，dry mouth and thirsty，fatigue and lack of strength， as well as night sweating and spontaneous sweating in the two groups were decreased when compared with those before treatment(P＜0.05)， and the scores above in the observation group were lower than those in the control group(P＜0.05). Before treatment，there was no significant difference being found in the comparisons of levels of FEV1，FEV1%pred，FEV1/ FVC between the two groups(P＞0.05)； after treatment， the indexes above in the two groups were increased when compared with those before treatment(P＜0.05)，and each index in the observation group was higher than that in the control group(P＜0.05). Before treatment， there was no significant difference being found in the comparison of levels of IMA and SAA between the two groups(P＞0.05). After treatment， levels of IMA and SAA in the two groups were decreased when compared with those before treatment(P＜0.05)，and the two levels in the observation group were lower than those in the control group(P＜0.05). During treatment，no serious adverse reactions occurred in both groups. Conclusion：The therapy of Yiqi Guben tang combined with tiotropium bromide inhalation powder has a significant curative effect in the treatment of COPD patients at stable stage，which can effectively improve clinical symptoms and the lung function，and regulate levels of SAA and IMA，with good medication safety.