Abstract：Objectives：To observe the clinical effect of Guyuan Huoxue Dishen tang combined with western medicine for stage Ⅲ chronic kidney disease. Methods： A total of 100 cases of patients with stage Ⅲ chronic kidney disease were randomly divided into the treatment group and the control group，50 cases in each group. The control group was treated with routine western medicine，and the treatment group was additionally treated with Guyuan Huoxue Dishen tang based on the treatment of the control group. Both groups were continuously treated for two months. The clinical effect and incidence of adverse reactions in the two groups were compared. Before and after treatment，the change of Chinese medicine syndrome scores and levels of serum creatinine(SCr)，24- hour urine protein，blood urea nitrogen(BUN)，interleukin- 6(IL- 6)， tumor necrosis factor-α(TNF-α) and high-sensitivity C-reactive protein(hs-CRP) in the two groups were observed. Results：The total effective rate was 86.00% in the treatment group， higher than that of 68.00% in the control group(P＜0.05). After treatment， the scores of soreness and weakness of waist and knees， complexion darkness， fatigue， and dizziness with insomnia in the two groups were decreased when compared with those before treatment(P＜0.05)， and the above four Chinese medicine syndrome scores in the treatment group were lower than those in the control group(P＜0.05). After treatment，the levels of SCr，24-hour urine protein and BUN in the two groups were decreased when compared with those before treatment(P＜0.05)，and the levels of SCr，24- hour urine protein and BUN in the treatment group were lower than those in the control group(P＜0.05). After treatment，the levels of IL- 6，TNF- α and hs- CRP in serum in the two groups were decreased when compared with those before treatment(P＜0.05)， and the levels of IL- 6， TNF- α and hs- CRP in serum in the treatment group were lower than those in the control group(P＜0.05). The incidence of adverse reactions was 8.00% in the treatment group， and 6.00% in the control group， there being no significance in the difference(P＞0.05). Conclusion：Guyuan Huoxue Dishen tang combined with western medicine for stage Ⅲ chronic kidney disease can alleviate the clinical symptoms of patients，improve kidney function，and reduce inflammatory response，with good safety.