复方丹参滴丸联合单硝酸异山梨酯治疗冠心病不稳定型心绞痛临床研究
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Clinical Study on Fufang Danshen Dripping Pills Combined with Isosorbide Mononitrate for Unstable Angina Pectoris of Coronary Heart Disease
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    摘要:

    目的:观察复方丹参滴丸联合单硝酸异山梨酯治疗冠心病不稳定型心绞痛的临床疗效。方法:选取80 例冠心病不稳定型心绞痛患者,按照随机数字表法分为对照组和观察组,每组40 例。对照组给予单硝酸异山梨酯片治疗,观察组在对照组基础上给予复方丹参滴丸治疗,2 组均治疗1 个月。比较2 组临床疗效及治疗前后心绞痛发作频率、心绞痛持续时间、硝酸甘油用量、中医证候积分、血脂指标、血管内皮功能指标、超敏C-反应蛋白(hs-CRP)、基质金属蛋白酶-9(MMP-9)、基质金属蛋白酶抑制物-1 (TIMP-1) 水平,记录不良反应。结果:观察组总有效率为90.00%,高于对照组的72.50% (P<0.05)。治疗后,2 组心绞痛发作频率、硝酸甘油用量及中医证候积分均较治疗前降低(P<0.05),心绞痛持续时间均较治疗前缩短(P<0.05);观察组心绞痛发作频率、硝酸甘油用量及中医证候积分均低于对照组(P<0.05),心绞痛持续时间短于对照组(P<0.05)。治疗后,2 组总胆固醇(TG)、甘油三酯(TC)、低密度脂蛋白胆固醇(LDL-C)、内皮素-1(ET-1)、MMP-9、hs-CRP水平均较治疗前降低(P<0.05),观察组TG、TC、LDL-C、ET-1、MMP-9、hs-CRP 水平均低于对照组(P<0.05);2 组脂联素(APN)、一氧化氮(NO) 水平均较治疗前升高(P<0.05), 观察组APN、NO 水平均高于对照组(P<0.05); 观察组高密度脂蛋白胆固醇(HDL-C) 水平较治疗前升高,且高于对照组(P<0.05)。2 组均未发现与治疗药物相关的严重不良反应。结论:复方丹参滴丸联合单硝酸异山梨酯治疗冠心病不稳定型心绞痛可提高临床疗效,有效调节患者的血脂水平,增强其血管内皮功能,安全性高。

    Abstract:

    Abstract: Objective: To observe the clinical effect of Fufang Danshen dripping pills combined with isosorbide mononitrate for unstable angina pectoris of coronary heart disease. Methods:A total of 80 cases of patients with unstable angina pectoris of coronary heart disease were selected and divided into the control group and the observation group according to the random number table method, 40 cases in each group. The control group was treated with isosorbide mononitrate tablets, and the observation group was additionally treated with Fufang Danshen dripping pills based on the treatment of the control group. Both groups were treated for one month. Clinical effects were compared between the two groups. Before and after treatment,the frequency of angina pectoris,duration of angina pectoris,dosage of nitroglycerin, Chinese medicine syndrome scores,blood lipid indexes,indexes of vascular endothelial function,as well as levels of highsensitivity C- reactive protein(hs- CRP), matrix metalloproteinase- 9(MMP- 9) and tissue inhibitor of metalloproteinases- 1 (TIMP- 1) were compared between the two groups. Incidences of adverse reactions were recorded. Results: The total effective rate was 90.00% in the observation group, higher than that of 72.50% in the control group(P<0.05). After treatment,the frequency of angina pectoris,dosage of nitroglycerin,Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment(P<0.05),and duration of angina pectoris was shortened(P< 0.05). After treatment,the frequency of angina pectoris,dosage of nitroglycerin,Chinese medicine syndrome score in the observation group were lower than those in the control group(P<0.05),and the duration of angina pectoris was shorter(P< 0.05). After treatment, levels of total cholesterol(TG), triglyceride(TC), low- density lipoprotein cholesterol(LDL- C), endothelin-1(ET-1),MMP-9 and hs-CRP in the two groups were decreased when compared with those before treatment (P<0.05), and the levels above in the observation group were lower than those in the control group(P<0.05). After treatment, adiponectin(APN) and nitric oxide(NO) in the two groups were increased when compared with those before treatment(P<0.05),and the two levels in the observation group were higher than those in the control group(P<0.05);high density lipoprotein cholesterol(HDL- C) level in the observation group was increased when compared with that before treatment,higher than that in the control group(P<0.05). No serious adverse reactions related to therapeutic medicines were found in the two groups. Conclusion:The therapy of Fufang Danshen dripping pills combined with isosorbide mononitrate in the treatment of unstable angina pectoris of coronary heart disease can enhance the clinical effect,effectively regulate blood lipid level,and strengthen patients' vascular endothelial function,with high safety.

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李金娥.复方丹参滴丸联合单硝酸异山梨酯治疗冠心病不稳定型心绞痛临床研究[J].新中医,2021,53(20):45-49

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  • 在线发布日期: 2021-10-22
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