Abstract： Objective： To observe the clinical effect of Fufang Danshen dripping pills combined with isosorbide mononitrate for unstable angina pectoris of coronary heart disease. Methods：A total of 80 cases of patients with unstable angina pectoris of coronary heart disease were selected and divided into the control group and the observation group according to the random number table method， 40 cases in each group. The control group was treated with isosorbide mononitrate tablets， and the observation group was additionally treated with Fufang Danshen dripping pills based on the treatment of the control group. Both groups were treated for one month. Clinical effects were compared between the two groups. Before and after treatment，the frequency of angina pectoris，duration of angina pectoris，dosage of nitroglycerin， Chinese medicine syndrome scores，blood lipid indexes，indexes of vascular endothelial function，as well as levels of highsensitivity C- reactive protein(hs- CRP)， matrix metalloproteinase- 9(MMP- 9) and tissue inhibitor of metalloproteinases- 1 (TIMP- 1) were compared between the two groups. Incidences of adverse reactions were recorded. Results： The total effective rate was 90.00% in the observation group， higher than that of 72.50% in the control group(P＜0.05). After treatment，the frequency of angina pectoris，dosage of nitroglycerin，Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment(P＜0.05)，and duration of angina pectoris was shortened(P＜ 0.05). After treatment，the frequency of angina pectoris，dosage of nitroglycerin，Chinese medicine syndrome score in the observation group were lower than those in the control group(P＜0.05)，and the duration of angina pectoris was shorter(P＜ 0.05). After treatment， levels of total cholesterol(TG)， triglyceride(TC)， low- density lipoprotein cholesterol(LDL- C)， endothelin-1(ET-1)，MMP-9 and hs-CRP in the two groups were decreased when compared with those before treatment (P＜0.05)， and the levels above in the observation group were lower than those in the control group(P＜0.05). After treatment， adiponectin(APN) and nitric oxide(NO) in the two groups were increased when compared with those before treatment(P＜0.05)，and the two levels in the observation group were higher than those in the control group(P＜0.05)；high density lipoprotein cholesterol(HDL- C) level in the observation group was increased when compared with that before treatment，higher than that in the control group(P＜0.05). No serious adverse reactions related to therapeutic medicines were found in the two groups. Conclusion：The therapy of Fufang Danshen dripping pills combined with isosorbide mononitrate in the treatment of unstable angina pectoris of coronary heart disease can enhance the clinical effect，effectively regulate blood lipid level，and strengthen patients' vascular endothelial function，with high safety.